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Tbio
TCTN2
Tectonic-2

Protein Summary
Description
Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for hedgehog signaling transduction (By similarity). This gene encodes a type I membrane protein that belongs to the tectonic family. Studies in mice suggest that this protein may be involved in hedgehog signaling, and essential for ciliogenesis. Mutations in this gene are associated with Meckel syndrome type 8. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303372
  • ENSP00000304941
  • ENSG00000168778
  • ENST00000426174
  • ENSP00000395171

Symbol
  • C12orf38
  • TECT2
  • MKS8
  • TECT2
  • JBTS24
  • C12orf38
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.76
histone modification site profile
0.75
cell line
0.61
cell type or tissue
0.6
small molecule perturbation
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.46   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.46   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
1
11
11
97
BMI-adjusted waist-hip ratio
6
12
16
96.9
waist circumference
1
7
7
93.9
BMI-adjusted waist circumference
1
7
7
93.8
adiponectin measurement
2
2
2
83.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
11
97
BMI-adjusted waist-hip ratio
16
96.9
waist circumference
7
93.9
BMI-adjusted waist circumference
7
93.8
adiponectin measurement
2
83.6
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tectonic family member 2
VGNC:5616
100615573
Dog
tectonic family member 2
VGNC:47214
477445
Horse
tectonic family member 2
VGNC:23968
100630826
Cow
tectonic family member 2
VGNC:35709
100847961
Pig
tectonic family member 2
100153315
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tectonic family member 2
Dog
tectonic family member 2
Horse
tectonic family member 2
Cow
tectonic family member 2
Pig
tectonic family member 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96GX1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (18)
Anchoring of the basal body to the plasma membrane (R-HSA-5620912)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cilium Assembly
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Anchoring of the basal body to the plasma membrane
Cilium Assembly
Organelle biogenesis and maintenance
Gene Ontology Terms (8)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (221)
1 – 10 of 221
TMEM231
Tbio
Novelty:  0.17100188
p_int:  0.99999996
p_ni:  4e-8
Score:  0.943
Data Source:  BioPlex,STRINGDB
PIGB
Tbio
Family:  Enzyme
Novelty:  0.05237713
p_int:  0.999977147
p_ni:  0.000022846
p_wrong:  7e-9
Data Source:  BioPlex
ALG12
Tbio
Family:  Enzyme
Novelty:  0.03785588
p_int:  0.999831275
p_ni:  0.000168725
Data Source:  BioPlex
GLRB
Tclin
Family:  IC
Novelty:  0.01721113
p_int:  0.999803439
p_ni:  0.000196561
p_wrong:  1e-9
Data Source:  BioPlex
JMJD8
Tbio
Novelty:  0.31175159
p_int:  0.999483461
p_ni:  0.000514451
p_wrong:  0.000002088
Data Source:  BioPlex
NXPE3
Tdark
Novelty:  1.5063521
p_int:  0.999427312
p_ni:  0.000568913
p_wrong:  0.000003775
Data Source:  BioPlex
TMEM8A
Tdark
Novelty:  0.15724279
p_int:  0.999413191
p_ni:  0.000113393
p_wrong:  0.000473416
Data Source:  BioPlex
HLA-DMB
Tbio
Novelty:  0.02289537
p_int:  0.998623601
p_ni:  0.000133386
p_wrong:  0.001243013
Score:  0.307
Data Source:  BioPlex,STRINGDB
GRID1
Tbio
Family:  IC
Novelty:  0.05041468
p_int:  0.997981417
p_ni:  0.001969736
p_wrong:  0.000048847
Data Source:  BioPlex
JAG2
Tbio
Novelty:  0.00176158
p_int:  0.997757763
p_ni:  0.002242216
p_wrong:  2.1e-8
Data Source:  BioPlex
Publication Statistics
PubMed Score  10.46

PubMed score by year
PubTator Score  3.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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