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Tbio
TAMM41
Phosphatidate cytidylyltransferase, mitochondrial

Protein Summary
Description
Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273037
  • ENSP00000273037
  • ENSG00000144559
  • ENST00000444133
  • ENSP00000388598
  • ENST00000455809
  • ENSP00000398596

Symbol
  • C3orf31
  • RAM41
  • TAM41
  • C3orf31
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
histone modification site profile
0.78
transcription factor binding site profile
0.78
transcription factor perturbation
0.74
transcription factor
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.24   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.24   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Anti-herpes simplex virus 2 IgG measurement
1
1
1
26
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Anti-herpes simplex virus 2 IgG measurement
1
26
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TAM41 mitochondrial translocator assembly and maintenance homolog
VGNC:7128
460174
Macaque
TAM41 mitochondrial translocator assembly and maintenance homolog [Source:HGNC Symbol;Acc:HGNC:25187]
Mouse
MGI:1916221
68971
Rat
RGD:1586150
362419
Dog
TAM41 mitochondrial translocator assembly and maintenance homolog
476532
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TAM41 mitochondrial translocator assembly and maintenance homolog
Macaque
TAM41 mitochondrial translocator assembly and maintenance homolog [Source:HGNC Symbol;Acc:HGNC:25187]
Mouse
Rat
Dog
TAM41 mitochondrial translocator assembly and maintenance homolog
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96BW9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (1)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
Name
Explore in Pharos
Explore in Source
Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (71)
1 – 10 of 71
SLC15A1
Tchem
Family: Transporter
Novelty: 0.00149723
p_int: 0.99997146
p_ni: 0.00002854
Data Source: BioPlex
CD70
Tbio
Novelty: 0.00420393
p_int: 0.999942466
p_ni: 0.000057533
p_wrong: 2e-9
Data Source: BioPlex
TNFSF8
Tbio
Novelty: 0.01292216
p_int: 0.99989957
p_ni: 0.000100419
p_wrong: 1.1e-8
Data Source: BioPlex
MGARP
Tbio
Novelty: 0.02883753
p_int: 0.999895638
p_ni: 0.000104362
Data Source: BioPlex
SLC2A12
Tbio
Family: Transporter
Novelty: 0.01455533
p_int: 0.999459163
p_ni: 0.000540837
p_wrong: 1e-9
Score: 0.245
Data Source: BioPlex,STRINGDB
FAM174A
Tdark
Novelty: 0.30693139
p_int: 0.999032415
p_ni: 0.000967585
Data Source: BioPlex
KLK1
Tchem
Family: Enzyme
Novelty: 0.00190157
p_int: 0.998377164
p_ni: 0.001622537
p_wrong: 2.99e-7
Data Source: BioPlex
LAMP2
Tbio
Novelty: 0.00168009
p_int: 0.998000823
p_ni: 0.001925837
p_wrong: 0.00007334
Data Source: BioPlex
LAMP3
Tbio
Novelty: 0.01677383
p_int: 0.997007492
p_ni: 0.002812137
p_wrong: 0.000180371
Data Source: BioPlex
APBA3
Tbio
Novelty: 0.05059532
p_int: 0.994624541
p_ni: 0.004859852
p_wrong: 0.000515607
Data Source: BioPlex
Publication Statistics
PubMed Score  17.24

PubMed score by year
PubTator Score  9.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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