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Tbio
CFHR4
Complement factor H-related protein 4

Protein Summary
Description
Involved in complement regulation. Can associate with lipoproteins and may play a role in lipid metabolism. This gene is a member of the complement factor H (CFH) gene family, and encodes one of the 5 CFH-related (CFHR) proteins. These 5 genes are closely linked to the CFH gene on chromosome 1q31-q32. The CFHRs are secreted plasma proteins synthesized primarily by the hepatocytes, and composed of highly-related short consensus repeats (SCRs). This protein enhances the cofactor activity of CFH, and is involved in complement regulation. It can associate with lipoproteins and may play a role in lipid metabolism. Alternatively spliced transcript variants encoding different isoforms (varying in the number of SCRs) have been described for this gene. [provided by RefSeq, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251424
  • ENSP00000251424
  • ENSG00000134365
  • ENST00000367416
  • ENSP00000356386
  • ENST00000608469
  • ENSP00000477162

Symbol
  • CFHL4
  • FHR4
  • FHR4
  • CFHL4
  • FHR-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.58
disease
0.53
tissue sample
0.49
cell type or tissue
0.44
small molecule perturbation
0.4


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.4   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.4   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (23)
1 – 10 of 23
C3
Tclin
Novelty:  0.00019115
Score:  0.986
Data Source:  Reactome,STRINGDB
ZBTB41
Tdark
Family:  TF
Novelty:  0.83922302
Score:  0.681
Data Source:  STRINGDB
CRP
Tbio
Novelty:  0.00001517
Score:  0.615
Data Source:  STRINGDB
CFI
Tbio
Novelty:  0.00271423
Score:  0.587
Data Source:  STRINGDB
CFB
Tchem
Novelty:  0.00102672
Score:  0.585
Data Source:  STRINGDB
ARMS2
Tbio
Novelty:  0.00455168
Score:  0.559
Data Source:  STRINGDB
DUS2
Tbio
Family:  Enzyme
Novelty:  0.05121878
Score:  0.55
Data Source:  STRINGDB
DDX28
Tbio
Family:  Enzyme
Novelty:  0.16760542
Score:  0.547
Data Source:  STRINGDB
MYBPH
Tbio
Novelty:  0.00247863
Score:  0.537
Data Source:  STRINGDB
CD46
Tbio
Novelty:  0.00098341
Score:  0.53
Data Source:  STRINGDB
Pathways (18)
Complement cascade (R-HSA-166658)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complement cascade
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Regulation of Complement cascade
Name
Explore in Pharos
Explore in Source
Complement cascade
Immune System
Innate Immune System
Regulation of Complement cascade
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
3
0
1.7
96.2
1
1
0
1.6
56.8
maculopapular eruption
1
1
0
7
46.9
response to phenytoin
1
1
0
7
46.9
atrophic macular degeneration
1
1
0
1.7
41.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.7
96.2
0
1.6
56.8
maculopapular eruption
0
7
46.9
response to phenytoin
0
7
46.9
atrophic macular degeneration
0
1.7
41.8
Find similar targets by:
Publication Statistics
PubMed Score 14.40
PubMed score by year
PubTator Score 11.62
PubTator score by year