Tbio NANOS1 Nanos homolog 1

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Nuclease / Nanos Homolog 1

DTO Classes

Protein / Enzyme / Nuclease / Nanos Homolog 1

Protein Summary

Description

May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion. This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2 and may be involved in regulating translation as a post-transcriptional repressor. Mutations in this gene are associated with spermatogenic impairment. [provided by RefSeq, Sep 2015]

Uniprot Accession IDs

• Q8WY41
• NOS-1

Gene Name

• NANOS1

Ensembl ID

• ENST00000425699
• ENSP00000393275
• ENSG00000188613

Symbol

• NOS1
• NOS1
• NOS-1
• SPGF12
• EC_Rep1a
• ZC2HC12A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.76
transcription factor perturbation	0.74
transcription factor	0.67
transcription factor binding site profile	0.61
histone modification site profile	0.55

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.97   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 284   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.97   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 284   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Keratoconus	Orphanet_156071	1	1	1		53.3
platelet crit	EFO_0007985	1	1	1		45.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Keratoconus	Orphanet_156071	1		53.3
platelet crit	EFO_0007985	1		45.7

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Orthologs (4)

1 – 4 of 4

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	nanos C2HC-type zinc finger 1	VGNC:12383	104008328
Mouse	nanos C2HC-type zinc finger 1	MGI:2669254	332397
Rat	nanos C2HC-type zinc finger 1	RGD:1308194	365494
Opossum	nanos C2HC-type zinc finger 1		100026306

Species	Name	OMA	EggNOG	Inparanoid
Chimp	nanos C2HC-type zinc finger 1
Mouse	nanos C2HC-type zinc finger 1
Rat	nanos C2HC-type zinc finger 1
Opossum	nanos C2HC-type zinc finger 1

Protein Structure (1 Structure, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8WY41-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Gene Ontology Terms (13)

Functions (3)

Components (2)

Processes (8)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
translation repressor activity	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
RNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
zinc ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (44)

Explore Interacting Targets

1 – 10 of 44

• See Interactions on String-DB

PUM2

Tbio

Novelty:  0.01849765

Score:  0.998

Data Source:  STRINGDB

CNOT1

Tbio

Novelty:  0.00362753

Score:  0.982

Data Source:  STRINGDB

TDRD7

Tbio

Family:  Epigenetic

Novelty:  0.03580848

Score:  0.892

Data Source:  STRINGDB

PUM1

Tbio

Novelty:  0.01536723

Score:  0.808

Data Source:  STRINGDB

TRIM3

Tbio

Novelty:  0.0188159

Score:  0.742

Data Source:  STRINGDB

TRIM2

Tbio

Novelty:  0.03571187

Score:  0.742

Data Source:  STRINGDB

DND1

Tbio

Novelty:  0.0287312

Score:  0.738

Data Source:  STRINGDB

DAZL

Tbio

Novelty:  0.00421428

Score:  0.706

Data Source:  STRINGDB

OTUD4

Tbio

Novelty:  0.17121119

Score:  0.673

Data Source:  STRINGDB

DDX20

Tbio

Family:  Enzyme

Novelty:  0.01854078

Score:  0.619

Data Source:  STRINGDB

Publication Statistics

PubMed Score  37.97

PubMed score by year

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PubTator Score  8.2

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Complete proteome
Cytoplasm
Disease mutation
Metal-binding
Reference proteome
Repressor
RNA-binding
Translation regulation
Zinc

GWAS Trait Find Similar Targets

No Header	No Header
Keratoconus
platelet crit