You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NANOS1
Nanos homolog 1

Protein Summary
Description
May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion. This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2 and may be involved in regulating translation as a post-transcriptional repressor. Mutations in this gene are associated with spermatogenic impairment. [provided by RefSeq, Sep 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000425699
  • ENSP00000393275
  • ENSG00000188613

Symbol
  • NOS1
  • NOS1
  • NOS-1
  • SPGF12
  • EC_Rep1a
  • ZC2HC12A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.76
transcription factor perturbation
0.74
transcription factor
0.67
transcription factor binding site profile
0.61
histone modification site profile
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.97   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 284   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.97   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 284   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (44)
PUM2
Tbio
Novelty:  0.01849765
Score:  0.998
Data Source:  STRINGDB
CNOT1
Tbio
Novelty:  0.00362753
Score:  0.982
Data Source:  STRINGDB
TDRD7
Tbio
Family:  Epigenetic
Novelty:  0.03580848
Score:  0.892
Data Source:  STRINGDB
PUM1
Tbio
Novelty:  0.01536723
Score:  0.808
Data Source:  STRINGDB
TRIM3
Tbio
Novelty:  0.0188159
Score:  0.742
Data Source:  STRINGDB
TRIM2
Tbio
Novelty:  0.03571187
Score:  0.742
Data Source:  STRINGDB
DND1
Tbio
Novelty:  0.0287312
Score:  0.738
Data Source:  STRINGDB
DAZL
Tbio
Novelty:  0.00421428
Score:  0.706
Data Source:  STRINGDB
OTUD4
Tbio
Novelty:  0.17121119
Score:  0.673
Data Source:  STRINGDB
DDX20
Tbio
Family:  Enzyme
Novelty:  0.01854078
Score:  0.619
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
53.3
platelet crit
1
1
1
45.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
53.3
platelet crit
1
45.7
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nanos C2HC-type zinc finger 1
VGNC:12383
104008328
Mouse
MGI:2669254
332397
Rat
RGD:1308194
365494
Opossum
nanos C2HC-type zinc finger 1
100026306
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nanos C2HC-type zinc finger 1
Mouse
Rat
Opossum
nanos C2HC-type zinc finger 1
Publication Statistics
PubMed Score 37.97
PubMed score by year
PubTator Score 8.20
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title