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Tbio
NANOS1
Nanos homolog 1

Protein Summary
Description
May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion. This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2 and may be involved in regulating translation as a post-transcriptional repressor. Mutations in this gene are associated with spermatogenic impairment. [provided by RefSeq, Sep 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000425699
  • ENSP00000393275
  • ENSG00000188613

Symbol
  • NOS1
  • NOS1
  • NOS-1
  • SPGF12
  • EC_Rep1a
  • ZC2HC12A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.76
transcription factor perturbation
0.74
transcription factor
0.67
transcription factor binding site profile
0.61
histone modification site profile
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.97   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 284   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.97   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 284   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Keratoconus
1
1
1
53.3
platelet crit
1
1
1
45.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Keratoconus
1
53.3
platelet crit
1
45.7
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nanos C2HC-type zinc finger 1
VGNC:12383
104008328
Mouse
MGI:2669254
332397
Rat
RGD:1308194
365494
Opossum
nanos C2HC-type zinc finger 1
100026306
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nanos C2HC-type zinc finger 1
Mouse
Rat
Opossum
nanos C2HC-type zinc finger 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8WY41-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (13)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (44)
1 – 10 of 44
PUM2
Tbio
Novelty:  0.01849765
Score:  0.998
Data Source:  STRINGDB
CNOT1
Tbio
Novelty:  0.00362753
Score:  0.982
Data Source:  STRINGDB
TDRD7
Tbio
Family:  Epigenetic
Novelty:  0.03580848
Score:  0.892
Data Source:  STRINGDB
PUM1
Tbio
Novelty:  0.01536723
Score:  0.808
Data Source:  STRINGDB
TRIM3
Tbio
Novelty:  0.0188159
Score:  0.742
Data Source:  STRINGDB
TRIM2
Tbio
Novelty:  0.03571187
Score:  0.742
Data Source:  STRINGDB
DND1
Tbio
Novelty:  0.0287312
Score:  0.738
Data Source:  STRINGDB
DAZL
Tbio
Novelty:  0.00421428
Score:  0.706
Data Source:  STRINGDB
OTUD4
Tbio
Novelty:  0.17121119
Score:  0.673
Data Source:  STRINGDB
DDX20
Tbio
Family:  Enzyme
Novelty:  0.01854078
Score:  0.619
Data Source:  STRINGDB
Publication Statistics
PubMed Score  37.97

PubMed score by year
PubTator Score  8.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer