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Tbio
ITLN1
Intelectin-1

Protein Summary
Description
Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner (PubMed:11313366, PubMed:26148048). Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) (PubMed:26148048). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris (PubMed:26148048). Does not bind human glycans (PubMed:26148048). Probably plays a role in the defense system against microorganisms (Probable). May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes (PubMed:16531507). Increases AKT phosphorylation in the absence and presence of insulin (PubMed:16531507). May interact with lactoferrin/LTF and increase its uptake, and may thereby ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326245
  • ENSP00000323587
  • ENSG00000179914

Symbol
  • INTL
  • ITLN
  • LFR
  • HL1
  • LFR
  • HL-1
  • INTL
  • ITLN
  • hIntL
  • omentin
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.78
cell type or tissue
0.54
cellular component
0.53
gene perturbation
0.51
phenotype
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 417.28   (req: < 5)
Gene RIFs: 155   (req: <= 3)
Antibodies: 286   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 417.28   (req: >= 5)
Gene RIFs: 155   (req: > 3)
Antibodies: 286   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
52.5
1
1
0
1.1
5.3
1
1
0
1.1
2.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
52.5
0
1.1
5.3
0
1.1
2.4
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Immune System
Innate Immune System
Gene Ontology Terms (14)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Protein-Protein Interactions (37)
1 – 10 of 37
ITLN2
Tbio
Novelty: 0.15601654
p_int: 1
Score: 0.864
Data Source: BioPlex,STRINGDB
NACC1
Tbio
Novelty: 0.03367769
p_int: 0.999999797
p_ni: 2.03e-7
Score: 0.332
Data Source: BioPlex,STRINGDB
ENDOG
Tbio
Family: Enzyme
Novelty: 0.00404275
p_int: 0.998666573
p_ni: 0.001333427
Score: 0.798
Data Source: BioPlex,STRINGDB
DNAJC12
Tbio
Novelty: 0.05214775
p_int: 0.989092322
p_ni: 0.010907676
p_wrong: 2e-9
Score: 0.19
Data Source: BioPlex,STRINGDB
RRAS
Tbio
Family: Enzyme
Novelty: 0.00786502
p_int: 0.904319103
p_ni: 0.095654601
p_wrong: 0.000026296
Score: 0.205
Data Source: BioPlex,STRINGDB
HSPA5
Tchem
Novelty: 0.00043424
p_int: 0.904299432
p_ni: 0.095700568
Data Source: BioPlex
TIPRL
Tbio
Novelty: 0.01885339
p_int: 0.807496517
p_ni: 0.192503449
p_wrong: 3.4e-8
Score: 0.29
Data Source: BioPlex,STRINGDB
SERPINA12
Tbio
Novelty: 0.00549132
Score: 0.835
Data Source: STRINGDB
RARRES2
Tbio
Novelty: 0.0029178
Score: 0.738
Data Source: STRINGDB
NAMPT
Tchem
Family: Enzyme
Novelty: 0.00093316
Score: 0.733
Data Source: STRINGDB
Publication Statistics
PubMed Score  417.28

PubMed score by year
PubTator Score  299.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer