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Tbio
PIWIL2
Piwi-like protein 2

Protein Summary
Description
Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity). During piRNA biosynthesis, plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slicer-competent' piRNA endoribonuclease that cleaves primary piRNAs, which are then loaded onto 'slicer-incompetent' PIWIL4 (By similarity). PIWIL2 slicing produces a pre-miRNA intermediate, which is then processed in mature piRNAs, and as well as a 16 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356766
  • ENSP00000349208
  • ENSG00000197181
  • ENST00000454009
  • ENSP00000406956
  • ENST00000521356
  • ENSP00000428267
  • ENST00000611073
  • ENSP00000478103

Symbol
  • HILI
  • CT80
  • HILI
  • mili
  • PIWIL1L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.79
gene perturbation
0.71
virus perturbation
0.59
cell type or tissue
0.53
PubMedID
0.5


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.99   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 241   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.99   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 241   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
2
50.6
1
1
0
1.1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
50.6
0
1.1
29
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
piwi like RNA-mediated gene silencing 2
VGNC:10219
472711
Macaque
piwi like RNA-mediated gene silencing 2
708028
Mouse
MGI:1930036
57746
Rat
RGD:1306964
306011
Dog
piwi like RNA-mediated gene silencing 2
VGNC:44593
486125
Species
Name
OMA
EggNOG
Inparanoid
Chimp
piwi like RNA-mediated gene silencing 2
Macaque
piwi like RNA-mediated gene silencing 2
Mouse
Rat
Dog
piwi like RNA-mediated gene silencing 2
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8TC59-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Gene Silencing by RNA (R-HSA-211000)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene Silencing by RNA
Reactome
Gene expression (Transcription)
Reactome
PIWI-interacting RNA (piRNA) biogenesis
Name
Explore in Pharos
Explore in Source
Gene Silencing by RNA
Gene expression (Transcription)
PIWI-interacting RNA (piRNA) biogenesis
Gene Ontology Terms (28)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (110)
1 – 10 of 110
TDRD1
Tbio
Family:  Epigenetic
Novelty:  0.04645566
Score:  0.997
Data Source:  STRINGDB
TDRD9
Tbio
Family:  Epigenetic
Novelty:  0.10913126
Score:  0.987
Data Source:  STRINGDB
MOV10L1
Tbio
Family:  Enzyme
Novelty:  0.09735465
Score:  0.986
Data Source:  STRINGDB
DDX4
Tbio
Family:  Enzyme
Novelty:  0.00692586
Score:  0.982
Data Source:  STRINGDB
MAEL
Tbio
Novelty:  0.01925239
Score:  0.98
Data Source:  STRINGDB
HSP90AA1
Tchem
Novelty:  0.00016774
Score:  0.98
Data Source:  STRINGDB
TDRD12
Tdark
Family:  Epigenetic
Novelty:  0.2276017
Score:  0.975
Data Source:  STRINGDB
HENMT1
Tdark
Family:  Enzyme
Novelty:  0.17427834
Score:  0.974
Data Source:  STRINGDB
TDRKH
Tbio
Family:  Epigenetic
Novelty:  0.0875409
Score:  0.969
Data Source:  STRINGDB
TDRD6
Tdark
Family:  Epigenetic
Novelty:  0.06480806
Score:  0.966
Data Source:  STRINGDB
Publication Statistics
PubMed Score  119.99

PubMed score by year
PubTator Score  69.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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