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Tbio
BAHD1
Bromo adjacent homology domain-containing 1 protein

Protein Summary
Description
Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon-stimulated genes, including IFNL1, IFNL2 and IFNL3.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000416165
  • ENSP00000396976
  • ENSG00000140320
  • ENST00000560846
  • ENSP00000454101
  • ENST00000561234
  • ENSP00000454150

Symbol
  • KIAA0945
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
transcription factor
0.78
cell type or tissue
0.72
microRNA
0.67
transcription factor binding site profile
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.95   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.95   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (55)
HIST1H2BA
Tbio
Novelty:  0.02431803
p_int:  0.999999963
p_ni:  1.1e-8
p_wrong:  2.6e-8
Score:  0.671
Data Source:  BioPlex,STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  0.998922096
p_ni:  0.000002602
p_wrong:  0.001075303
Score:  0.962
Data Source:  BioPlex,STRINGDB
H2AFZ
Tbio
Novelty:  0.00222512
p_int:  0.998640509
p_ni:  0.000001429
p_wrong:  0.001358063
Data Source:  BioPlex
HDAC2
Tclin
Family:  Epigenetic
Novelty:  0.0011024
Score:  0.939
Data Source:  STRINGDB
SUV39H1
Tchem
Family:  Epigenetic
Novelty:  0.00417439
Score:  0.918
Data Source:  STRINGDB
MTA2
Tbio
Family:  TF
Novelty:  0.01525806
Score:  0.915
Data Source:  STRINGDB
CHD4
Tchem
Family:  Epigenetic
Novelty:  0.00826969
Score:  0.91
Data Source:  STRINGDB
RBBP7
Tbio
Novelty:  0.01795364
Score:  0.906
Data Source:  STRINGDB
RBBP4
Tbio
Novelty:  0.01062843
Score:  0.905
Data Source:  STRINGDB
SIRT1
Tchem
Family:  Epigenetic
Novelty:  0.00022265
Score:  0.902
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
2
2
88
blood metabolite measurement
2
1
2
82.9
3
2
2
1.1
75.7
mean reticulocyte volume
1
1
1
66.8
intelligence
3
2
1
5.6
65.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
88
blood metabolite measurement
2
82.9
2
1.1
75.7
mean reticulocyte volume
1
66.8
intelligence
1
5.6
65.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
bromo adjacent homology domain containing 1
VGNC:11827
453335
Macaque
bromo adjacent homology domain containing 1
702982
Mouse
MGI:2139371
228536
Rat
RGD:1563127
362194
Dog
bromo adjacent homology domain containing 1
VGNC:38370
487495
Species
Name
OMA
EggNOG
Inparanoid
Chimp
bromo adjacent homology domain containing 1
Macaque
bromo adjacent homology domain containing 1
Mouse
Rat
Dog
bromo adjacent homology domain containing 1
Publication Statistics
PubMed Score 9.95
PubMed score by year
PubTator Score 4.12
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title