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Tbio
CHST13
Carbohydrate sulfotransferase 13

Protein Classes
Protein Summary
Description
Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Transfers sulfate to the C4 hydroxyl of beta1,4-linked GalNAc that is substituted with a beta-linked glucuronic acid at the C-3 hydroxyl. No activity toward dermatan. The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to the C4 hydroxyl of beta-1,4-linked N-acetylgalactosamine (GalNAc) flanked by glucuronic acid residue in chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319340
  • ENSP00000317404
  • ENSG00000180767

Symbol
  • C4ST3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.65
histone modification site profile
0.63
pathway
0.63
tissue
0.53
gene perturbation
0.47


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.16   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 123   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.16   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carbohydrate sulfotransferase 13
VGNC:11372
471065
Macaque
carbohydrate sulfotransferase 13
716548
Mouse
MGI:1919047
71797
Rat
RGD:1562825
500257
Cow
carbohydrate sulfotransferase 13
VGNC:27341
523460
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carbohydrate sulfotransferase 13
Macaque
carbohydrate sulfotransferase 13
Mouse
Rat
Cow
carbohydrate sulfotransferase 13
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8NET6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
Chondroitin sulfate biosynthesis (R-HSA-2022870)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chondroitin sulfate biosynthesis
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Glycosaminoglycan metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Chondroitin sulfate biosynthesis
Chondroitin sulfate/dermatan sulfate metabolism
Glycosaminoglycan metabolism
Metabolism
Metabolism of carbohydrates
Protein-Protein Interactions (44)
1 – 10 of 44
PCSK1N
Tbio
Novelty: 0.02656799
p_int: 0.999930907
p_ni: 0.000065297
p_wrong: 0.000003796
Data Source: BioPlex
NUCB1
Tchem
Novelty: 0.0040312
p_int: 0.944568568
p_ni: 0.055431428
p_wrong: 4e-9
Data Source: BioPlex
CHST7
Tbio
Family: Enzyme
Novelty: 0.18769086
Score: 0.972
Data Source: STRINGDB
CHST3
Tbio
Family: Enzyme
Novelty: 0.01744095
Score: 0.971
Data Source: STRINGDB
CHST15
Tbio
Family: Enzyme
Novelty: 0.03950241
Score: 0.97
Data Source: STRINGDB
UST
Tbio
Family: Enzyme
Novelty: 0.03897672
Score: 0.963
Data Source: STRINGDB
CHST2
Tbio
Family: Enzyme
Novelty: 0.04128083
Score: 0.933
Data Source: STRINGDB
VCAN
Tbio
Novelty: 0.00110986
Score: 0.92
Data Source: STRINGDB
CSPG4
Tbio
Novelty: 0.0038499
Score: 0.913
Data Source: STRINGDB
DCN
Tbio
Novelty: 0.00073027
Score: 0.912
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.16

PubMed score by year
PubTator Score  2.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer