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Tbio
CCNY
Cyclin-Y

Protein Summary
Description
Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription. Cyclins, such as CCNY, control cell division cycles and regulate cyclin-dependent kinases (e.g., CDC2; MIM 116940) (Li et al., 2009 [PubMed 18060517]).[supplied by OMIM, May 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265375
  • ENSP00000265375
  • ENSG00000108100
  • ENST00000339497
  • ENSP00000344275
  • ENST00000374704
  • ENSP00000363836
  • ENST00000374706
  • ENSP00000363838

Symbol
  • C10orf9
  • CBCP1
  • CFP1
  • CCNX
  • CFP1
  • CBCP1
  • C10orf9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
kinase perturbation
0.96
virus perturbation
0.88
microRNA
0.86
cell type or tissue
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.49   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 176   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.49   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
45.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
45.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin Y
VGNC:11685
450402
Macaque
cyclin Y
698889
Mouse
MGI:1915224
67974
Rat
RGD:1565969
361261
Dog
cyclin Y
VGNC:38908
606967
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin Y
Macaque
cyclin Y
Mouse
Rat
Dog
cyclin Y
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8ND76-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (68)
1 – 10 of 68
CCNYL1
Tdark
Novelty: 0.45350824
p_int: 0.999996811
p_ni: 0.000003188
p_wrong: 1e-9
Score: 0.717
Data Source: BioPlex,STRINGDB
GJB7
Tbio
Novelty: 0.12555147
p_int: 0.99995727
p_ni: 0.000042726
p_wrong: 5e-9
Data Source: BioPlex
HBG2
Tbio
Novelty: 0.01145628
p_int: 0.999938568
p_ni: 0.000061045
p_wrong: 3.87e-7
Data Source: BioPlex
TMEM185A
Tdark
Novelty: 0.0262898
p_int: 0.999885158
p_ni: 0.000114818
p_wrong: 2.4e-8
Data Source: BioPlex
CCNL2
Tbio
Novelty: 0.03667817
p_int: 0.999829866
p_ni: 0.000170117
p_wrong: 1.7e-8
Score: 0.731
Data Source: BioPlex,STRINGDB
HOXB5
Tbio
Family: TF
Novelty: 0.01119871
p_int: 0.998721977
p_ni: 0.001273721
p_wrong: 0.000004302
Score: 0.221
Data Source: BioPlex,STRINGDB
KIFAP3
Tbio
Novelty: 0.01902437
p_int: 0.99833167
p_ni: 0.001660896
p_wrong: 0.000007435
Score: 0.175
Data Source: BioPlex,STRINGDB
GPR141
Tdark
Family: GPCR
Novelty: 0.30711523
p_int: 0.997553242
p_ni: 0.002441546
p_wrong: 0.000005211
Data Source: BioPlex
SDC1
Tbio
Novelty: 0.00044792
p_int: 0.994156665
p_ni: 0.001908803
p_wrong: 0.003934533
Score: 0.158
Data Source: BioPlex,STRINGDB
CDK16
Tchem
Family: Kinase
Novelty: 0.02579684
p_int: 0.99375203
p_ni: 0.000236503
p_wrong: 0.006011467
Score: 0.962
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  72.49

PubMed score by year
PubTator Score  22.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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