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Tbio
ZIC4
Zinc finger protein ZIC 4

Protein Summary
Description
Binds to DNA. This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development, and have been associated with X-linked visceral heterotaxy and holoprosencephaly type 5. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 1, a related family member on chromosome 3. Heterozygous deletion of these linked genes is involved in Dandy-Walker malformation, which is a congenital cerebellar malformation. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000383075
  • ENSP00000372553
  • ENSG00000174963
  • ENST00000425731
  • ENSP00000397695
  • ENST00000473123
  • ENSP00000420775
  • ENST00000484399
  • ENSP00000417855
  • ENST00000491672
  • ENSP00000418277
  • ENST00000525172
  • ENSP00000435509
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.67
PubMedID
0.57
transcription factor
0.54
gene perturbation
0.52
cell line
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.8   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 381   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.8   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 381   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (46)
DNER
Tbio
Novelty:  0.02192523
Score:  0.842
Data Source:  STRINGDB
AMPH
Tbio
Novelty:  0.00201043
Score:  0.793
Data Source:  STRINGDB
ARHGAP26
Tbio
Family:  Enzyme
Novelty:  0.02409941
Score:  0.761
Data Source:  STRINGDB
DPYSL5
Tbio
Family:  Enzyme
Novelty:  0.0052536
Score:  0.759
Data Source:  STRINGDB
ZIC1
Tbio
Family:  TF
Novelty:  0.00491601
Score:  0.746
Data Source:  STRINGDB
PNMA2
Tbio
Novelty:  0.00162709
Score:  0.713
Data Source:  STRINGDB
DPP6
Tbio
Family:  Enzyme
Novelty:  0.00435138
Score:  0.702
Data Source:  STRINGDB
LGI1
Tbio
Novelty:  0.00204066
Score:  0.695
Data Source:  STRINGDB
PRKCG
Tchem
Family:  Kinase
Novelty:  0.00291817
Score:  0.691
Data Source:  STRINGDB
TP53BP1
Tbio
Family:  Epigenetic
Novelty:  0.00131256
Score:  0.677
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical surface area measurement
1
5
0
16.3
97.1
risky sexual behaviour measurement
1
2
2
60.9
smoking status measurement
2
1
2
50.6
1
1
0
1.1
49.5
age at first sexual intercourse measurement
2
2
2
47.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical surface area measurement
0
16.3
97.1
risky sexual behaviour measurement
2
60.9
smoking status measurement
2
50.6
0
1.1
49.5
age at first sexual intercourse measurement
2
47.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Zic family member 4
VGNC:7140
470956
Macaque
Zic family member 4
712982
Mouse
MGI:107201
22774
Rat
RGD:1307298
315882
Dog
Zic family member 4
VGNC:49755
485704
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Zic family member 4
Macaque
Zic family member 4
Mouse
Rat
Dog
Zic family member 4
Publication Statistics
PubMed Score 37.80
PubMed score by year
PubTator Score 17.36
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title