You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MYCT1
Myc target protein 1

Protein Summary
Description
May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367245
  • ENSP00000356214
  • ENSG00000120279

Symbol
  • MTLC
  • MTMC1
  • MTLC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.66
cell type or tissue
0.63
kinase perturbation
0.54
transcription factor perturbation
0.54
microRNA
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.69   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.69   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (22)
1 – 10 of 22
ADGRL4
Tbio
Family:  GPCR
Novelty:  0.0250826
Score:  0.773
Data Source:  STRINGDB
CKAP4
Tbio
Novelty:  0.02104039
Score:  0.654
Data Source:  STRINGDB
EMCN
Tbio
Novelty:  0.01537879
Score:  0.625
Data Source:  STRINGDB
NGLY1
Tbio
Family:  Enzyme
Novelty:  0.01017395
Score:  0.571
Data Source:  STRINGDB
DHX15
Tbio
Family:  Enzyme
Novelty:  0.0134377
Score:  0.561
Data Source:  STRINGDB
LANCL1
Tbio
Novelty:  0.06479031
Score:  0.554
Data Source:  STRINGDB
DDX42
Tchem
Family:  Enzyme
Novelty:  0.06068814
Score:  0.535
Data Source:  STRINGDB
ACR
Tchem
Family:  Enzyme
Novelty:  0.00068607
Score:  0.516
Data Source:  STRINGDB
ZNF543
Tdark
Family:  TF
Novelty:  0.94885014
Score:  0.511
Data Source:  STRINGDB
ENGASE
Tchem
Family:  Enzyme
Novelty:  0.00920032
Score:  0.507
Data Source:  STRINGDB
Pathways (1)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: pid
Validated targets of C-MYC transcriptional activation
Name
Explore in Pharos
Explore in Source
Validated targets of C-MYC transcriptional activation
Gene Ontology Terms (2)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
2
2
1.2
90.7
age at first sexual intercourse measurement
1
1
1
82
serum gamma-glutamyl transferase measurement
1
1
1
74.5
myeloid white cell count
1
1
1
72.3
lymphocyte count
2
1
2
68
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
1.2
90.7
age at first sexual intercourse measurement
1
82
serum gamma-glutamyl transferase measurement
1
74.5
myeloid white cell count
1
72.3
lymphocyte count
2
68
Find similar targets by:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MYC target 1
VGNC:3497
736710
Macaque
MYC target 1
711296
Mouse
MGI:1915882
68632
Rat
RGD:1311467
292264
Dog
MYC target 1
VGNC:43530
612005
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MYC target 1
Macaque
MYC target 1
Mouse
Rat
Dog
MYC target 1
Publication Statistics
PubMed Score 18.69
PubMed score by year
PubTator Score 7.49
PubTator score by year