Tbio MYCT1 Myc target protein 1

Protein Summary

Description

May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation (By similarity).

Uniprot Accession IDs

• Q8N699
• Q8N396
• Q8TBE8
• Q9H763

Gene Name

• MYCT1

Ensembl ID

• ENST00000367245
• ENSP00000356214
• ENSG00000120279

Symbol

• MTLC
• MTMC1
• MTLC

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.66
cell type or tissue	0.63
kinase perturbation	0.54
transcription factor perturbation	0.54
microRNA	0.51

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.74   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 116   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.74   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0