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Tbio
ESX1
Homeobox protein ESX1

Protein Summary
Description
May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover. This gene encodes a dual-function 65 kDa protein that undergoes proteolytic cleavage to produce a 45 kDa N-terminal fragment with a paired-like homeodomain and a 20 kDa C-terminal fragment with a proline-rich domain. The C-terminal fragment localizes to the cytoplasm while the N-terminal fragment localizes exclusively to the nucleus. In contrast to human, the mouse homolog has a novel PN/PF motif in the C-terminus and is paternally imprinted in placental tissue. This gene likely plays a role in placental development and spermatogenesis. [provided by RefSeq, Jan ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372588
  • ENSP00000361669
  • ENSG00000123576

Symbol
  • ESX1L
  • ESX1R
  • ESX1L
  • ESXR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.7
PubMedID
0.63
biological process
0.62
molecular function
0.6
protein domain
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 332.39   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 332.39   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
LHX4
Tbio
Family:  TF
Novelty:  0.02047732
Score:  0.863
Data Source:  STRINGDB
PDE6B
Tclin
Family:  Enzyme
Novelty:  0.001105
Score:  0.843
Data Source:  STRINGDB
POU1F1
Tbio
Family:  TF
Novelty:  0.0052029
Score:  0.804
Data Source:  STRINGDB
LHX3
Tbio
Family:  TF
Novelty:  0.00784158
Score:  0.786
Data Source:  STRINGDB
ELF3
Tbio
Family:  TF
Novelty:  0.00284335
Score:  0.785
Data Source:  STRINGDB
TGIF2LX
Tbio
Family:  TF
Novelty:  0.10755032
Score:  0.714
Data Source:  STRINGDB
SOX3
Tbio
Family:  TF
Novelty:  0.00280653
Score:  0.685
Data Source:  STRINGDB
TBX19
Tbio
Family:  TF
Novelty:  0.01599679
Score:  0.615
Data Source:  STRINGDB
CGAS
Tchem
Family:  Enzyme
Novelty:  0.00239778
Score:  0.596
Data Source:  STRINGDB
PROKR2
Tchem
Family:  GPCR
Novelty:  0.01400881
Score:  0.59
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Dog
ESX homeobox 1
VGNC:54139
102153369
Cow
ESX homeobox 1
VGNC:28612
616174
Species
Name
OMA
EggNOG
Inparanoid
Dog
ESX homeobox 1
Cow
ESX homeobox 1
Publication Statistics
PubMed Score 332.39
PubMed score by year
PubTator Score 27.42
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title