Tbio ESX1 Homeobox protein ESX1

Protein Summary

Description

May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover. This gene encodes a dual-function 65 kDa protein that undergoes proteolytic cleavage to produce a 45 kDa N-terminal fragment with a paired-like homeodomain and a 20 kDa C-terminal fragment with a proline-rich domain. The C-terminal fragment localizes to the cytoplasm while the N-terminal fragment localizes exclusively to the nucleus. In contrast to human, the mouse homolog has a novel PN/PF motif in the C-terminus and is paternally imprinted in placental tissue. This gene likely plays a role in placental development and spermatogenesis. [provided by RefSeq, Jan 2010]

Uniprot Accession IDs

• Q8N693
• B0QYU3
• Q7Z6K7

Gene Name

• ESX1

Ensembl ID

• ENST00000372588
• ENSP00000361669
• ENSG00000123576

Symbol

• ESX1L
• ESX1R
• ESX1L
• ESXR1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.7
PubMedID	0.63
biological process	0.62
molecular function	0.6
protein domain	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 332.39   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 128   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 332.39   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (54)

Explore Interacting Targets

1 – 10 of 54

• See Interactions on String-DB

LHX4

Tbio

Family:  TF

Novelty:  0.02047732

Score:  0.863

Data Source:  STRINGDB

PDE6B

Tclin

Family:  Enzyme

Novelty:  0.001105

Score:  0.843

Data Source:  STRINGDB

POU1F1

Tbio

Family:  TF

Novelty:  0.0052029

Score:  0.804

Data Source:  STRINGDB

LHX3

Tbio

Family:  TF

Novelty:  0.00784158

Score:  0.786

Data Source:  STRINGDB

ELF3

Tbio

Family:  TF

Novelty:  0.00284335

Score:  0.785

Data Source:  STRINGDB

TGIF2LX

Tbio

Family:  TF

Novelty:  0.10755032

Score:  0.714

Data Source:  STRINGDB

SOX3

Tbio

Family:  TF

Novelty:  0.00280653

Score:  0.685

Data Source:  STRINGDB

TBX19

Tbio

Family:  TF

Novelty:  0.01599679

Score:  0.615

Data Source:  STRINGDB

CGAS

Tchem

Family:  Enzyme

Novelty:  0.00239778

Score:  0.596

Data Source:  STRINGDB

PROKR2

Tchem

Family:  GPCR

Novelty:  0.01400881

Score:  0.59

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (1)

KEGG (1)

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5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Signaling pathways regulating pluripotency of stem cells	139 targets	path:hsa04550

Name	Explore in Pharos	Explore in Source
Signaling pathways regulating pluripotency of stem cells	139 targets	path:hsa04550

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (10)

Functions (4)

Components (3)

Processes (3)

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10

1 – 4 of 4

GO Term	Evidence	Assigned by
DNA-binding transcription repressor activity, RNA polymerase II-specific	Inferred from Direct Assay (IDA)	NTNU_SB
sequence-specific DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
RNA polymerase II regulatory region sequence-specific DNA binding	Inferred from Mutant Phenotype (IMP)	NTNU_SB
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB

Disease Associations ()

No disease associations found

GWAS Traits (0)

No GWAS traits found

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
Cytoplasm
DNA-binding
Homeobox
Nucleus
Polymorphism
Reference proteome
Repeat
Repressor
Transcription

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
embryo phenotype
growth/size/body region phenotype

IDG Resources

No IDG generated resources found

Orthologs (2)

1 – 2 of 2

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Dog	ESX homeobox 1	VGNC:54139	102153369
Cow	ESX homeobox 1	VGNC:28612	616174

Species	Name	OMA	EggNOG	Inparanoid
Dog	ESX homeobox 1
Cow	ESX homeobox 1

Publication Statistics

PubMed Score 332.39

PubMed score by year

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PubTator Score 27.42

PubTator score by year

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Related Publications

Text Mined References (14)

GeneRif Annotations (5)

Items per page:

10

0 of 0

PMID	Year	Title