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Tbio
NPAS3
Neuronal PAS domain-containing protein 3

Protein Summary
Description
May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to psychotic illness (By similarity). This gene encodes a member of the basic helix-loop-helix and PAS domain-containing family of transcription factors. The encoded protein is localized to the nucleus and may regulate genes involved in neurogenesis. Chromosomal abnormalities that affect the coding potential of this gene are associated with schizophrenia and cognitive disability. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346562
  • ENSP00000319610
  • ENSG00000151322
  • ENST00000356141
  • ENSP00000348460
  • ENST00000357798
  • ENSP00000350446
  • ENST00000547068
  • ENSP00000449542
  • ENST00000548645
  • ENSP00000448916

Symbol
  • BHLHE12
  • MOP6
  • PASD6
  • MOP6
  • PASD6
  • bHLHe12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
phenotype
0.85
protein domain
0.73
disease
0.68
biological process
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.82   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.82   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (55)
KIAA0391
Tbio
Family:  Enzyme
Novelty:  0.02276396
Score:  0.751
Data Source:  STRINGDB
HARS
Tchem
Family:  Enzyme
Novelty:  0.01271582
Score:  0.748
Data Source:  STRINGDB
POU3F2
Tbio
Family:  TF
Novelty:  0.00649458
Score:  0.733
Data Source:  STRINGDB
ELOC
Tbio
Novelty:  0.00964847
Score:  0.731
Data Source:  STRINGDB
AKAP6
Tbio
Family:  Enzyme
Novelty:  0.02961416
Score:  0.723
Data Source:  STRINGDB
POU3F3
Tbio
Family:  TF
Novelty:  0.00954977
Score:  0.707
Data Source:  STRINGDB
EGLN3
Tclin
Novelty:  0.00643992
Score:  0.701
Data Source:  STRINGDB
POU3F1
Tbio
Family:  TF
Novelty:  0.00290081
Score:  0.697
Data Source:  STRINGDB
POU3F4
Tbio
Family:  TF
Novelty:  0.00836257
Score:  0.687
Data Source:  STRINGDB
XKR4
Tbio
Novelty:  0.11544767
Score:  0.619
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
insomnia measurement
1
1
0
1.1
56.4
smoking status measurement
1
1
1
51.7
self reported educational attainment
1
1
1
42.3
intelligence
2
2
1
5.7
40.6
intraocular pressure measurement
1
2
2
33
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
insomnia measurement
0
1.1
56.4
smoking status measurement
1
51.7
self reported educational attainment
1
42.3
intelligence
1
5.7
40.6
intraocular pressure measurement
2
33
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neuronal PAS domain protein 3
VGNC:3344
452849
Macaque
neuronal PAS domain protein 3
717281
Mouse
MGI:1351610
27386
Dog
neuronal PAS domain protein 3 [Source:HGNC Symbol;Acc:HGNC:19311]
Cow
neuronal PAS domain protein 3 [Source:HGNC Symbol;Acc:HGNC:19311]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neuronal PAS domain protein 3
Macaque
neuronal PAS domain protein 3
Mouse
Dog
neuronal PAS domain protein 3 [Source:HGNC Symbol;Acc:HGNC:19311]
Cow
neuronal PAS domain protein 3 [Source:HGNC Symbol;Acc:HGNC:19311]
Publication Statistics
PubMed Score 44.82
PubMed score by year
PubTator Score 27.78
PubTator score by year
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Related Publications
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PMID
Year
Title