NPAS3
Neuronal PAS domain-containing protein 3
Protein Summary
May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to psychotic illness (By similarity). This gene encodes a member of the basic helix-loop-helix and PAS domain-containing family of transcription factors. The encoded protein is localized to the nucleus and may regulate genes involved in neurogenesis. Chromosomal abnormalities that affect the coding potential of this gene are associated with schizophrenia and cognitive disability. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
- ENST00000346562
- ENSP00000319610
- ENSG00000151322
- ENST00000356141
- ENSP00000348460
- ENST00000357798
- ENSP00000350446
- ENST00000547068
- ENSP00000449542
- ENST00000548645
- ENSP00000448916
- BHLHE12
- MOP6
- PASD6
- MOP6
- PASD6
- bHLHe12
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 1 | ||
phenotype | 0.85 | ||
protein domain | 0.73 | ||
disease | 0.68 | ||
biological process | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 44.82 (req: < 5)
Gene RIFs: 20 (req: <= 3)
Antibodies: 122 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 44.82 (req: >= 5)
Gene RIFs: 20 (req: > 3)
Antibodies: 122 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (55)
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (3)
Components (3)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
insomnia measurement | 1 | 1 | 0 | 1.1 | 56.4 | ||||
smoking status measurement | 1 | 1 | 1 | 51.7 | |||||
self reported educational attainment | 1 | 1 | 1 | 42.3 | |||||
intelligence | 2 | 2 | 1 | 5.7 | 40.6 | ||||
intraocular pressure measurement | 1 | 2 | 2 | 33 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
insomnia measurement | 0 | 1.1 | 56.4 | ||||
smoking status measurement | 1 | 51.7 | |||||
self reported educational attainment | 1 | 42.3 | |||||
intelligence | 1 | 5.7 | 40.6 | ||||
intraocular pressure measurement | 2 | 33 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | neuronal PAS domain protein 3 | VGNC:3344 | 452849 | |||||
Macaque | neuronal PAS domain protein 3 | 717281 | ||||||
Mouse | MGI:1351610 | 27386 | ||||||
Dog | neuronal PAS domain protein 3 [Source:HGNC Symbol;Acc:HGNC:19311] | |||||||
Cow | neuronal PAS domain protein 3 [Source:HGNC Symbol;Acc:HGNC:19311] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | neuronal PAS domain protein 3 | |||||
Macaque | neuronal PAS domain protein 3 | |||||
Mouse | ||||||
Dog | neuronal PAS domain protein 3 [Source:HGNC Symbol;Acc:HGNC:19311] | |||||
Cow | neuronal PAS domain protein 3 [Source:HGNC Symbol;Acc:HGNC:19311] | |||||
Publication Statistics
PubMed Score 44.82
PubMed score by year
PubTator Score 27.78
PubTator score by year
Related Publications
Text Mined References (38)
GeneRif Annotations (20)
Items per page:
0 of 0
PMID | Year | Title |
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