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Tbio
PASD1
Circadian clock protein PASD1

Protein Summary
Description
Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body (PubMed:25936801). Acts as a nuclear repressor of the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock components (PubMed:25936801). Inhibits circadian clock function in cancer cells, when overexpressed (PubMed:25936801). This gene encodes a protein that is thought to function as a transcription factor. The protein is a cancer-associated antigen that can stimulate autologous T-cell responses, and it is therefore considered to be a potential immunotherapeutic target for the treatment of various hematopoietic malignancies, including diffuse large B-cell lymphoma. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370357
  • ENSP00000359382
  • ENSG00000166049

Symbol
  • CT63
  • CT64
  • OXTES1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.63
cell line
0.45
phenotype
0.43
transcription factor
0.36
disease
0.34


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.5   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 252   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.5   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 252   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
ZIC3
Tbio
Family:  TF
Novelty:  0.00904398
Score:  0.924
Data Source:  STRINGDB
RBBP7
Tbio
Novelty:  0.01795364
Score:  0.906
Data Source:  STRINGDB
CHD4
Tchem
Family:  Epigenetic
Novelty:  0.00826969
Score:  0.9
Data Source:  STRINGDB
SIRT2
Tchem
Family:  Epigenetic
Novelty:  0.00093962
Score:  0.9
Data Source:  STRINGDB
BAHD1
Tbio
Novelty:  0.1601376
Score:  0.9
Data Source:  STRINGDB
RBBP4
Tbio
Novelty:  0.01062843
Score:  0.9
Data Source:  STRINGDB
SIRT1
Tchem
Family:  Epigenetic
Novelty:  0.00022265
Score:  0.9
Data Source:  STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
Score:  0.9
Data Source:  STRINGDB
MTA2
Tbio
Family:  TF
Novelty:  0.01525806
Score:  0.9
Data Source:  STRINGDB
GATAD2A
Tbio
Novelty:  0.05599551
Score:  0.9
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Circadian rhythm related genes
WikiPathways
Circadian rhythm related genes
WikiPathways
Effects of Nitric Oxide
WikiPathways
Photodynamic therapy-induced HIF-1 survival signaling
WikiPathways
Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
Name
Explore in Pharos
Explore in Source
Circadian rhythm related genes
Circadian rhythm related genes
Effects of Nitric Oxide
Photodynamic therapy-induced HIF-1 survival signaling
Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PAS domain containing repressor 1
107971225
Macaque
PAS domain containing repressor 1
100429911
Dog
PAS domain containing repressor 1
VGNC:44269
102156152
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PAS domain containing repressor 1
Macaque
PAS domain containing repressor 1
Dog
PAS domain containing repressor 1
Publication Statistics
PubMed Score 11.50
PubMed score by year
PubTator Score 9.46
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title