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Tbio
GDF7
Growth/differentiation factor 7

Protein Summary
Description
May play an active role in the motor area of the primate neocortex. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in the differentiation of tendon cells and spinal cord interneurons. A mutation in this gene may be associated with increased risk for Barrett's esophagus and esophageal adenocarcinoma. [provided by RefSeq, Sep 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272224
  • ENSP00000272224
  • ENSG00000143869

Symbol
  • BMP12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.9
protein domain
0.73
tissue sample
0.67
histone modification site profile
0.54
PubMedID
0.5


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.11   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 238   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.11   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 238   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pelvic organ prolapse
1
1
0
1.1
79.2
prostate carcinoma
1
1
0
1.1
65.8
2
1
0
1.2
59.1
1
1
0
1.1
49.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pelvic organ prolapse
0
1.1
79.2
prostate carcinoma
0
1.1
65.8
0
1.2
59.1
0
1.1
49.6
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
growth differentiation factor 7
VGNC:10651
470322
Mouse
MGI:95690
238057
Rat
RGD:620105
252833
Horse
growth differentiation factor 7
VGNC:51314
100147101
Cow
growth differentiation factor 7
VGNC:29305
286859
Species
Name
OMA
EggNOG
Inparanoid
Chimp
growth differentiation factor 7
Mouse
Rat
Horse
growth differentiation factor 7
Cow
growth differentiation factor 7
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q7Z4P5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Axon guidance
KEGG
TGF-beta signaling pathway
KEGG
Hippo signaling pathway
KEGG
Cytokine-cytokine receptor interaction
Name
Explore in Pharos
Explore in Source
Axon guidance
TGF-beta signaling pathway
Hippo signaling pathway
Cytokine-cytokine receptor interaction
Protein-Protein Interactions (35)
1 – 10 of 35
BMPR2
Tchem
Family: Kinase
Novelty: 0.00155912
Score: 0.913
Data Source: STRINGDB
BMPR1B
Tchem
Family: Kinase
Novelty: 0.00698763
Score: 0.912
Data Source: STRINGDB
BMP7
Tbio
Novelty: 0.00049424
Score: 0.911
Data Source: STRINGDB
BMPR1A
Tchem
Family: Kinase
Novelty: 0.00343928
Score: 0.812
Data Source: STRINGDB
TNMD
Tbio
Novelty: 0.00775497
Score: 0.803
Data Source: STRINGDB
NOG
Tbio
Novelty: 0.0010373
Score: 0.79
Data Source: STRINGDB
CHRD
Tbio
Novelty: 0.00347659
Score: 0.745
Data Source: STRINGDB
AMHR2
Tbio
Family: Kinase
Novelty: 0.00479939
Score: 0.723
Data Source: STRINGDB
PAEP
Tbio
Novelty: 0.00125851
Score: 0.647
Data Source: STRINGDB
SCX
Tbio
Family: TF
Novelty: 0.01222743
Score: 0.581
Data Source: STRINGDB
Publication Statistics
PubMed Score  63.11

PubMed score by year
PubTator Score  20.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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