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Tdark
COX8C
Cytochrome c oxidase subunit 8C, mitochondrial

Protein Summary
Description
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342144
  • ENSP00000340568
  • ENSG00000187581
  • ENST00000620478
  • ENSP00000480706
  • ENSG00000277018

Symbol
  • COX8-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.85
molecular function
0.6
cellular component
0.57
cell line
0.46
PubMedID
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.08   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 18   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.08   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 18   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (36)
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Non-alcoholic fatty liver disease (NAFLD)
KEGG
Alzheimer disease
KEGG
Huntington disease
KEGG
Thermogenesis
KEGG
Cardiac muscle contraction
Name
Explore in Pharos
Explore in Source
Non-alcoholic fatty liver disease (NAFLD)
Alzheimer disease
Huntington disease
Thermogenesis
Cardiac muscle contraction
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (43)
1 – 10 of 43
COX8A
Tbio
Family: Enzyme
Novelty: 0.00796737
Score: 0.891
Data Source: STRINGDB
COX4I2
Tbio
Family: Enzyme
Novelty: 0.00965049
Score: 0.857
Data Source: STRINGDB
COX6A2
Tbio
Family: Enzyme
Novelty: 0.05368739
Score: 0.759
Data Source: STRINGDB
COX4I1
Tbio
Family: Enzyme
Novelty: 0.00208873
Score: 0.753
Data Source: STRINGDB
COX7B2
Tdark
Family: Enzyme
Novelty: 0.92736353
Score: 0.74
Data Source: STRINGDB
COX6A1
Tbio
Family: Enzyme
Novelty: 0.05543187
Score: 0.728
Data Source: STRINGDB
COX6B2
Tbio
Family: Enzyme
Novelty: 0.1103017
Score: 0.711
Data Source: STRINGDB
COX5A
Tbio
Family: Enzyme
Novelty: 0.02110193
Score: 0.667
Data Source: STRINGDB
NDUFA4
Tclin
Family: Enzyme
Novelty: 0.03103013
Score: 0.658
Data Source: STRINGDB
COX7B
Tbio
Family: Enzyme
Novelty: 0.09076141
Score: 0.657
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.08

PubMed score by year
PubTator Score  4.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer