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Tbio
TRMT11
tRNA (guanine(10)-N2)-methyltransferase homolog

Protein Summary
Description
Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334379
  • ENSP00000333934
  • ENSG00000066651
  • ENST00000368332
  • ENSP00000357316
  • ENST00000479748
  • ENSP00000433724

Symbol
  • C6orf75
  • TRM11
  • MDS024
  • C6orf75
  • TRMT11-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.83
protein domain
0.73
transcription factor binding site profile
0.69
tissue sample
0.63
cell type or tissue
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.97   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.97   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (225)
GALC
Tbio
Family:  Enzyme
Novelty:  0.00203532
p_int:  0.999910828
p_ni:  0.000089172
Score:  0.209
Data Source:  BioPlex,STRINGDB
TRMT112
Tbio
Family:  Enzyme
Novelty:  0.05451623
p_int:  0.99924663
p_ni:  0.00075337
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
NARS
Tbio
Family:  Enzyme
Novelty:  0.01124207
p_int:  0.990921302
p_ni:  0.009078695
p_wrong:  2e-9
Score:  0.256
Data Source:  BioPlex,STRINGDB
PSD2
Tdark
Novelty:  0.03272803
p_int:  0.792556554
p_ni:  0.207290305
p_wrong:  0.000153141
Data Source:  BioPlex
VTN
Tbio
Family:  TF
Novelty:  0.00046861
p_int:  0.786033773
p_ni:  0.213768298
p_wrong:  0.000197929
Score:  0.179
Data Source:  BioPlex,STRINGDB
TRMT6
Tbio
Family:  Enzyme
Novelty:  0.06718902
Score:  0.939
Data Source:  STRINGDB
NOP2
Tbio
Family:  Enzyme
Novelty:  0.01664777
Score:  0.932
Data Source:  STRINGDB
METTL1
Tbio
Family:  Enzyme
Novelty:  0.03641249
Score:  0.93
Data Source:  STRINGDB
TRMT1
Tbio
Family:  Enzyme
Novelty:  0.01795504
Score:  0.93
Data Source:  STRINGDB
FTSJ3
Tbio
Family:  Enzyme
Novelty:  0.01888973
Score:  0.924
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA modification in the nucleus and cytosol
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA modification in the nucleus and cytosol
tRNA processing
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
1
9
9
95.8
BMI-adjusted waist-hip ratio
2
9
10
95.8
hip circumference
2
8
8
90.4
BMI-adjusted hip circumference
2
5
6
83.9
urate measurement
2
2
2
78.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
9
95.8
BMI-adjusted waist-hip ratio
10
95.8
hip circumference
8
90.4
BMI-adjusted hip circumference
6
83.9
urate measurement
2
78.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tRNA methyltransferase 11 homolog
VGNC:3774
745151
Macaque
tRNA methyltransferase 11 homolog
712712
Mouse
MGI:1920931
73681
Rat
RGD:727798
378794
Dog
tRNA methyltransferase 11 homolog
VGNC:47854
476285
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tRNA methyltransferase 11 homolog
Macaque
tRNA methyltransferase 11 homolog
Mouse
Rat
Dog
tRNA methyltransferase 11 homolog
Publication Statistics
PubMed Score 7.97
PubMed score by year
PubTator Score 1.93
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title