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Tbio
BHLHA15
Class A basic helix-loop-helix protein 15

Protein Summary
Description
Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3' (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314018
  • ENSP00000326391
  • ENSG00000180535
  • ENST00000609256
  • ENSP00000476312

Symbol
  • BHLHB8
  • MIST1
  • MIST1
  • BHLHB8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.89
molecular function
0.73
phenotype
0.49
transcription factor
0.48
metabolite
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.35   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.35   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (16)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (83)
1 – 10 of 83
HIST1H1C
Tbio
Novelty: 0.00937936
p_int: 0.999981999
p_ni: 0.000018001
Data Source: BioPlex
CHCHD2
Tbio
Novelty: 0.02070317
p_int: 0.999975632
p_ni: 5.6e-8
p_wrong: 0.000024312
Score: 0.165
Data Source: BioPlex,STRINGDB
PARP12
Tbio
Family: Enzyme
Novelty: 0.14117321
p_int: 0.999945525
p_ni: 0.000054475
Data Source: BioPlex
FAF1
Tbio
Novelty: 0.01741429
p_int: 0.999944932
p_ni: 0.000055068
Data Source: BioPlex
RNF41
Tbio
Family: Enzyme
Novelty: 0.02458297
p_int: 0.999764881
p_ni: 0.000234981
p_wrong: 1.38e-7
Data Source: BioPlex
PHF10
Tbio
Family: Epigenetic
Novelty: 0.06950506
p_int: 0.999724335
p_ni: 0.000275665
Data Source: BioPlex
C1QBP
Tbio
Novelty: 0.00278686
p_int: 0.999643068
p_ni: 0.000356932
Data Source: BioPlex
HIST1H1T
Tdark
Novelty: 0.01211318
p_int: 0.999203877
p_ni: 0.000796121
p_wrong: 2e-9
Data Source: BioPlex
RPS27A
Tbio
Novelty: 0.01148413
p_int: 0.998235615
p_ni: 0.001764385
Data Source: BioPlex
BAG1
Tbio
Novelty: 0.0033615
p_int: 0.998150378
p_ni: 0.001798427
p_wrong: 0.000051195
Data Source: BioPlex
Publication Statistics
PubMed Score  20.35

PubMed score by year
PubTator Score  21.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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