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Tbio
ISLR2
Immunoglobulin superfamily containing leucine-rich repeat protein 2

Protein Classes
Protein Summary
Description
Required for axon extension during neural development.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361742
  • ENSP00000355402
  • ENSG00000167178
  • ENST00000435464
  • ENSP00000411443
  • ENST00000453268
  • ENSP00000411834
  • ENST00000565159
  • ENSP00000455531
  • ENST00000565540
  • ENSP00000458080

Symbol
  • KIAA1465
  • LINX
  • LINX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
transcription factor binding site profile
0.76
transcription factor
0.68
gene perturbation
0.59
PubMedID
0.59


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.27   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.27   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
immunoglobulin superfamily containing leucine rich repeat 2
701357
Mouse
MGI:2444277
320563
Rat
RGD:6497037
100910729
Cow
immunoglobulin superfamily containing leucine rich repeat 2
VGNC:30299
617436
Chicken
immunoglobulin superfamily containing leucine rich repeat
CGNC:14606
769957
Species
Name
OMA
EggNOG
Inparanoid
Macaque
immunoglobulin superfamily containing leucine rich repeat 2
Mouse
Rat
Cow
immunoglobulin superfamily containing leucine rich repeat 2
Chicken
immunoglobulin superfamily containing leucine rich repeat
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6UXK2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (29)
1 – 10 of 29
LAPTM4B
Tbio
Novelty: 0.01162533
Score: 0.803
Data Source: STRINGDB
N4BP2
Tbio
Novelty: 0.12823967
Score: 0.746
Data Source: STRINGDB
ADGRL1
Tbio
Family: GPCR
Novelty: 0.00957739
Score: 0.685
Data Source: STRINGDB
ADGRL2
Tbio
Family: GPCR
Novelty: 0.00985539
Score: 0.685
Data Source: STRINGDB
ADGRL3
Tbio
Family: GPCR
Novelty: 0.00268343
Score: 0.685
Data Source: STRINGDB
SLC1A2
Tchem
Family: Transporter
Novelty: 0.00086733
Score: 0.652
Data Source: STRINGDB
PDE10A
Tclin
Family: Enzyme
Novelty: 0.00318215
Score: 0.621
Data Source: STRINGDB
VASN
Tbio
Novelty: 0.05424159
Score: 0.597
Data Source: STRINGDB
TFAP2D
Tdark
Family: TF
Novelty: 0.18255944
Score: 0.545
Data Source: STRINGDB
ATP4A
Tclin
Family: Transporter
Novelty: 0.00008783
Score: 0.543
Data Source: STRINGDB
Publication Statistics
PubMed Score  13.27

PubMed score by year
PubTator Score  49.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer