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Tbio
ANGPTL8
Angiopoietin-like protein 8

Protein Summary
Description
Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels (PubMed:22569073, PubMed:22809513, PubMed:23150577). May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storage in the fed state (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252453
  • ENSP00000252453
  • ENSG00000130173
  • ENST00000616433
  • ENSP00000479969

Symbol
  • C19orf80
  • RIFL
  • RIFL
  • TD26
  • PRO1185
  • PVPA599
  • C19orf80
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 252.3   (req: < 5)
Gene RIFs: 83   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 252.3   (req: >= 5)
Gene RIFs: 83   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (22)
ANGPTL3
Tclin
Novelty:  0.00595539
Score:  0.994
Data Source:  Reactome,STRINGDB
LPL
Tchem
Family:  Enzyme
Novelty:  0.00057058
Score:  0.964
Data Source:  STRINGDB
GPIHBP1
Tbio
Novelty:  0.01241227
Score:  0.957
Data Source:  STRINGDB
ANGPTL4
Tbio
Novelty:  0.00237867
Score:  0.944
Data Source:  STRINGDB
INS
Tbio
Novelty:  0.00000499
Score:  0.851
Data Source:  STRINGDB
ANGPTL5
Tbio
Novelty:  0.0856739
Score:  0.731
Data Source:  STRINGDB
ANGPTL1
Tbio
Novelty:  0.03123564
Score:  0.726
Data Source:  STRINGDB
ANGPTL7
Tbio
Novelty:  0.03893082
Score:  0.725
Data Source:  STRINGDB
ANGPTL6
Tbio
Novelty:  0.00538738
Score:  0.707
Data Source:  STRINGDB
ANGPTL2
Tbio
Novelty:  0.01134724
Score:  0.677
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Assembly of active LPL and LIPC lipase complexes (R-HSA-8963889)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of active LPL and LIPC lipase complexes
Reactome
Plasma lipoprotein assembly, remodeling, and clearance
Reactome
Plasma lipoprotein remodeling
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Assembly of active LPL and LIPC lipase complexes
Plasma lipoprotein assembly, remodeling, and clearance
Plasma lipoprotein remodeling
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (40)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
50
16
61
10
99.6
total cholesterol measurement
15
15
19
3.2
99.6
low density lipoprotein cholesterol measurement
12
14
17
2.4
99.3
reticulocyte count
7
6
11
96.3
ANGPTL8 measurement
1
1
1
96.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
61
10
99.6
total cholesterol measurement
19
3.2
99.6
low density lipoprotein cholesterol measurement
17
2.4
99.3
reticulocyte count
11
96.3
ANGPTL8 measurement
1
96.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
angiopoietin like 8
106994638
Mouse
MGI:3643534
624219
Rat
RGD:2320121
100361444
Dog
angiopoietin like 8
VGNC:37864
102155149
Horse
angiopoietin like 8 [Source:HGNC Symbol;Acc:HGNC:24933]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
angiopoietin like 8
Mouse
Rat
Dog
angiopoietin like 8
Horse
angiopoietin like 8 [Source:HGNC Symbol;Acc:HGNC:24933]
Publication Statistics
PubMed Score 252.30
PubMed score by year
PubTator Score 48.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title