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Tbio
CLEC4G
C-type lectin domain family 4 member G

Protein Summary
Description
Binds mannose, N-acetylglucosamine (GlcNAc) and fucose, but not galactose, in a Ca(2+)-dependent manner, in vitro. (Microbial infection) Acts as a receptor for Japanese encephalitis virus. (Microbial infection) Acts as a receptor for Ebolavirus. (Microbial infection) Acts as a receptor for SARS coronavirus/SARS-CoV. (Microbial infection) Acts as a receptor for Lassa virus and Lymphocytic choriomeningitis virus glycoprotein (PubMed:22156524, PubMed:22673088). This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the T-cell immune response. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328853
  • ENSP00000327599
  • ENSG00000182566

Symbol
  • LP2698
  • UNQ431
  • DTTR431
  • LSECtin
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.68
protein domain
0.58
tissue sample
0.52
tissue
0.49
virus perturbation
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.74   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.74   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (24)
PILRA
Tbio
Novelty:  0.05154386
Score:  0.903
Data Source:  Reactome,STRINGDB
LGALS3
Tchem
Novelty:  0.00032754
Score:  0.662
Data Source:  STRINGDB
TYRO3
Tchem
Family:  Kinase
Novelty:  0.00233016
Score:  0.63
Data Source:  STRINGDB
BACE1
Tchem
Family:  Enzyme
Novelty:  0.00042175
Score:  0.588
Data Source:  STRINGDB
TYROBP
Tbio
Family:  Enzyme
Novelty:  0.00410031
Score:  0.58
Data Source:  STRINGDB
GTPBP1
Tbio
Novelty:  0.00160825
Score:  0.565
Data Source:  STRINGDB
CLEC5A
Tbio
Novelty:  0.01710591
Score:  0.552
Data Source:  STRINGDB
AXL
Tchem
Family:  Kinase
Novelty:  0.00132459
Score:  0.532
Data Source:  STRINGDB
RASAL3
Tbio
Novelty:  0.22098972
Score:  0.53
Data Source:  STRINGDB
MCEMP1
Tdark
Novelty:  0.14180782
Score:  0.53
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
4
5
95.6
leukocyte count
2
4
4
91.2
resistin measurement
1
2
0
6.2
91.1
myeloid white cell count
2
2
2
86.2
aspartate aminotransferase measurement
1
1
0
9.5
73.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
5
95.6
leukocyte count
4
91.2
resistin measurement
0
6.2
91.1
myeloid white cell count
2
86.2
aspartate aminotransferase measurement
0
9.5
73.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-type lectin domain family 4 member G
VGNC:10971
742238
Mouse
MGI:1923113
75863
Rat
RGD:1597482
689004
Dog
C-type lectin domain family 4 member G
VGNC:39333
484999
Horse
C-type lectin domain family 4 member G
100066617
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-type lectin domain family 4 member G
Mouse
Rat
Dog
C-type lectin domain family 4 member G
Horse
C-type lectin domain family 4 member G
Publication Statistics
PubMed Score 29.74
PubMed score by year
PubTator Score 17.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title