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Tdark
TMED8
Protein TMED8

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216468
  • ENSP00000216468
  • ENSG00000100580

Symbol
  • FAM15B
  • FAM15B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.81
virus perturbation
0.72
transcription factor perturbation
0.61
transcription factor binding site profile
0.55
cell line
0.46


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.45   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 90   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.45   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
81
myeloid white cell count
2
2
2
74.7
leukocyte count
2
2
2
67.5
granulocyte count
1
1
1
54.4
sum of basophil and neutrophil counts
1
1
1
51.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
81
myeloid white cell count
2
74.7
leukocyte count
2
67.5
granulocyte count
1
54.4
sum of basophil and neutrophil counts
1
51.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane p24 trafficking protein family member 8
VGNC:12467
743639
Mouse
MGI:1923480
382620
Rat
Dog
transmembrane p24 trafficking protein family member 8
VGNC:47441
490807
Horse
transmembrane p24 trafficking protein family member 8
VGNC:24171
100059164
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane p24 trafficking protein family member 8
Mouse
Rat
Dog
transmembrane p24 trafficking protein family member 8
Horse
transmembrane p24 trafficking protein family member 8
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6PL24-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (25)
1 – 10 of 25
P2RX1
Tchem
Family:  IC
Novelty:  0.00286826
p_int:  0.999999535
p_ni:  4.65e-7
Score:  0.209
Data Source:  BioPlex,STRINGDB
GPR183
Tchem
Family:  GPCR
Novelty:  0.02005679
p_int:  0.999986342
p_ni:  0.000003781
p_wrong:  0.000009877
Score:  0.181
Data Source:  BioPlex,STRINGDB
TSEN2
Tbio
Family:  Enzyme
Novelty:  0.04151213
p_int:  0.999959723
p_ni:  0.00004015
p_wrong:  1.27e-7
Score:  0.187
Data Source:  BioPlex,STRINGDB
FZD10
Tbio
Family:  GPCR
Novelty:  0.02786933
p_int:  0.999951137
p_ni:  0.000048857
p_wrong:  6e-9
Data Source:  BioPlex
PTGER3
Tclin
Family:  GPCR
Novelty:  0.0012681
p_int:  0.99994186
p_ni:  0.000058135
p_wrong:  5e-9
Data Source:  BioPlex
KCNJ10
Tbio
Family:  IC
Novelty:  0.00273462
p_int:  0.995148044
p_ni:  0.004851941
p_wrong:  1.6e-8
Score:  0.214
Data Source:  BioPlex,STRINGDB
CD8B
Tbio
Novelty:  0.00382722
p_int:  0.919084595
p_ni:  0.080887386
p_wrong:  0.000028019
Data Source:  BioPlex
SMAD2
Tbio
Family:  TF
Novelty:  0.00040166
p_int:  0.886225282
p_ni:  0.060694164
p_wrong:  0.053080554
Data Source:  BioPlex
FUNDC1
Tbio
Novelty:  0.02333176
p_int:  0.84970648
p_ni:  0.000008363
p_wrong:  0.150285157
Data Source:  BioPlex
RAP1GDS1
Tbio
Family:  Enzyme
Novelty:  0.06140479
p_int:  0.756229169
p_ni:  0.243770831
Data Source:  BioPlex
Publication Statistics
PubMed Score  0.45

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer