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Tdark
CCDC174
Coiled-coil domain-containing protein 174

Protein Summary
Description
Probably involved in neuronal development. The protein encoded by this gene is found in the nucleus, where it interacts with eukaryotic translation initiation factor 4A, isoform 3. The encoded protein appears to be a part of the exon junction complex, which is involved in RNA processing, translation, and nonsense-mediated mRNA decay. A mutation in this gene has been associated with infantile hypotonia with psychomotor retardation. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000383794
  • ENSP00000373304
  • ENSG00000154781

Symbol
  • C3orf19
  • IHPM
  • IHPMR
  • C3orf19
  • HSPC212
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.89
histone modification site profile
0.8
cell type or tissue
0.73
virus perturbation
0.64
transcription factor
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.1   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 48   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.1   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 48   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (30)
1 – 10 of 30
TATDN2
Tdark
Family:  Enzyme
Novelty:  1.40236433
Score:  0.903
Data Source:  STRINGDB
EIF4A3
Tchem
Novelty:  0.00981496
Score:  0.737
Data Source:  STRINGDB
GPR22
Tbio
Family:  GPCR
Novelty:  0.1822753
Score:  0.692
Data Source:  STRINGDB
PPP1R35
Tdark
Family:  Enzyme
Novelty:  0.47022173
Score:  0.669
Data Source:  STRINGDB
GHSR
Tclin
Family:  GPCR
Novelty:  0.00165638
Score:  0.654
Data Source:  STRINGDB
CHST8
Tbio
Family:  Enzyme
Novelty:  0.03489772
Score:  0.629
Data Source:  STRINGDB
DNM1L
Tchem
Novelty:  0.00151314
Score:  0.626
Data Source:  STRINGDB
IRAK2
Tbio
Family:  Kinase
Novelty:  0.01496024
Score:  0.605
Data Source:  STRINGDB
BAHD1
Tbio
Novelty:  0.1601376
Score:  0.596
Data Source:  STRINGDB
DNAJB9
Tbio
Novelty:  0.00536296
Score:  0.595
Data Source:  STRINGDB
Gene Ontology Terms (2)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sleep measurement
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sleep measurement
1
39.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 174
VGNC:1758
470757
Mouse
MGI:2444652
232236
Rat
RGD:1305225
297458
Dog
coiled-coil domain containing 174
VGNC:38813
100686384
Horse
coiled-coil domain containing 174
VGNC:16143
100055882
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 174
Mouse
Rat
Dog
coiled-coil domain containing 174
Horse
coiled-coil domain containing 174
Publication Statistics
PubMed Score 3.10
PubMed score by year
PubTator Score 2.00
PubTator score by year