Protein Summary
May play a role in the control of cellular aging and survival. This gene is a member of a gene family which encodes proteins with a basic helix-loop-helix domain. Other members of this gene family encode proteins which function as transcription factors, either enhancing or inhibiting transcription depending on the activity of other DNA binding proteins. The coding region of this gene is located entirely within the terminal exon. The encoded protein may be involved in the survival of neurons (PMID: 15034937). Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2011]
- ENST00000361229
- ENSP00000354675
- ENSG00000198908
- ENST00000372735
- ENSP00000361820
- ENST00000447531
- ENSP00000405893
- ENST00000448867
- ENSP00000391722
- ENST00000457056
- ENSP00000403226
- KIAA1701
- GASP3
- p60TRP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
kinase perturbation | 0.93 | ||
virus perturbation | 0.72 | ||
tissue sample | 0.68 | ||
small molecule perturbation | 0.59 | ||
histone modification site profile | 0.53 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.53 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 27 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.53 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 27 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0