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Tbio
FAHD1
Acylpyruvase FAHD1, mitochondrial

Protein Classes
Protein Summary
Description
Probable mitochondrial acylpyruvase which is able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro (PubMed:15551868, PubMed:21878618). Also has oxaloacetate decarboxylase activity (PubMed:25575590).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382666
  • ENSP00000372112
  • ENSG00000180185
  • ENST00000382668
  • ENSP00000372114
  • ENST00000427358
  • ENSP00000398053
  • ENST00000615972
  • ENSP00000482534

Symbol
  • C16orf36
  • YISKL
  • YISKL
  • C16orf36
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
transcription factor binding site profile
0.86
histone modification site profile
0.85
virus perturbation
0.72
cell type or tissue
0.57


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.97   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 56   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.97   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 56   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
fumarylacetoacetate hydrolase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:14169]
Mouse
MGI:1915886
68636
Rat
RGD:1304560
302980
Horse
fumarylacetoacetate hydrolase domain containing 1
VGNC:17778
100067938
Cow
fumarylacetoacetate hydrolase domain containing 1
VGNC:28708
509273
Species
Name
OMA
EggNOG
Inparanoid
Macaque
fumarylacetoacetate hydrolase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:14169]
Mouse
Rat
Horse
fumarylacetoacetate hydrolase domain containing 1
Cow
fumarylacetoacetate hydrolase domain containing 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q6P587-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Citric acid cycle (TCA cycle) (R-HSA-71403)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Citric acid cycle (TCA cycle)
Reactome
Metabolism
Reactome
Pyruvate metabolism and Citric Acid (TCA) cycle
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Citric acid cycle (TCA cycle)
Metabolism
Pyruvate metabolism and Citric Acid (TCA) cycle
The citric acid (TCA) cycle and respiratory electron transport
Gene Ontology Terms (10)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (50)
1 – 10 of 50
UBR3
Tbio
Family: Enzyme
Novelty: 0.14930754
p_int: 0.999907434
p_ni: 0.000092566
Data Source: BioPlex
PNPT1
Tbio
Family: Enzyme
Novelty: 0.00339969
p_int: 0.999064509
p_ni: 0.000935491
Score: 0.325
Data Source: BioPlex,STRINGDB
CPT2
Tchem
Family: Enzyme
Novelty: 0.00345645
p_int: 0.998970733
p_ni: 0.001029267
Score: 0.245
Data Source: BioPlex,STRINGDB
NDUFS6
Tclin
Family: Enzyme
Novelty: 0.07910252
p_int: 0.997950151
p_ni: 0.00204724
p_wrong: 0.000002608
Data Source: BioPlex
DHTKD1
Tbio
Family: Enzyme
Novelty: 0.0381406
p_int: 0.97378783
p_ni: 0.025189448
p_wrong: 0.001022722
Score: 0.249
Data Source: BioPlex,STRINGDB
OR10H3
Tdark
Family: oGPCR
Novelty: 18
p_int: 0.967904792
p_ni: 0.030446279
p_wrong: 0.001648929
Score: 0.228
Data Source: BioPlex,STRINGDB
FSD1
Tbio
Novelty: 0.03452477
p_int: 0.967904792
p_ni: 0.030446279
p_wrong: 0.001648929
Data Source: BioPlex
CLUH
Tbio
Novelty: 0.14027296
p_int: 0.84393799
p_ni: 0.15606201
Score: 0.193
Data Source: BioPlex,STRINGDB
FAH
Tbio
Family: Enzyme
Novelty: 0.00456617
Score: 0.968
Data Source: STRINGDB
FH
Tbio
Family: Enzyme
Novelty: 0.00455957
Score: 0.893
Data Source: STRINGDB
Publication Statistics
PubMed Score  14.97

PubMed score by year
PubTator Score  5.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer