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Tdark
WASHC2A
WASH complex subunit 2A

Protein Summary
Description
Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required f ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282633
  • ENSP00000282633
  • ENSG00000099290
  • ENST00000351071
  • ENSP00000344037

Symbol
  • FAM21A
  • FAM21B
  • FAM21A
  • FAM21B
  • bA98I6.1
  • bA56A21.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.29   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 14   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.29   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 14   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
42.3
mean reticulocyte volume
1
1
1
36.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
42.3
mean reticulocyte volume
1
36.5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q641Q2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (32)
1 – 10 of 32
WASHC3
Tdark
Novelty:  0.18307321
p_int:  0.999999998
p_ni:  2e-9
Score:  0.995
Data Source:  BioPlex,STRINGDB
WASHC1
Tbio
Novelty:  0.09242196
p_int:  0.999999997
p_wrong:  3e-9
Score:  0.992
Data Source:  BioPlex,STRINGDB
CAPZA2
Tbio
Novelty:  0.14014918
p_int:  0.999999996
p_ni:  4e-9
Score:  0.219
Data Source:  BioPlex,STRINGDB
WASHC5
Tbio
Novelty:  0.02909884
Score:  0.996
Data Source:  STRINGDB
WASHC4
Tdark
Novelty:  0.05930527
Score:  0.995
Data Source:  STRINGDB
WASHC2D
Tdark
Novelty:  0.09738237
Score:  0.831
Data Source:  STRINGDB
WASHC2C
Tbio
Novelty:  0.09738237
Score:  0.831
Data Source:  STRINGDB
CAPZA1
Tbio
Novelty:  0.03448517
Score:  0.79
Data Source:  STRINGDB
CAPZB
Tbio
Novelty:  0.03509224
Score:  0.789
Data Source:  STRINGDB
WASH2P
Tdark
Novelty:  2.49106532
Score:  0.72
Data Source:  STRINGDB
Publication Statistics
PubMed Score  0.29

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer