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Tbio
ALS2CL
ALS2 C-terminal-like protein

Protein Summary
Description
Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318962
  • ENSP00000313670
  • ENSG00000178038
  • ENST00000415953
  • ENSP00000413223

Symbol
  • RN49018
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
virus perturbation
0.88
small molecule perturbation
0.7
histone modification site profile
0.65
molecular function
0.63


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.56   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.56   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ALS2 C-terminal like
VGNC:1730
470812
Macaque
ALS2 C-terminal like
712772
Mouse
MGI:2447532
235633
Rat
RGD:1305208
316017
Dog
ALS2 C-terminal like
VGNC:54571
484786
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ALS2 C-terminal like
Macaque
ALS2 C-terminal like
Mouse
Rat
Dog
ALS2 C-terminal like
Pathways (4)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
RAB GEFs exchange GTP for GDP on RABs
Reactome
Rab regulation of trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
RAB GEFs exchange GTP for GDP on RABs
Rab regulation of trafficking
Vesicle-mediated transport
Protein-Protein Interactions (43)
1 – 10 of 43
RAB5A
Tbio
Family: Enzyme
Novelty: 0.00111347
Score: 0.968
Data Source: STRINGDB
RAB5C
Tbio
Family: Enzyme
Novelty: 0.02952779
Score: 0.939
Data Source: STRINGDB
GDI1
Tbio
Novelty: 0.01710945
Score: 0.9
Data Source: STRINGDB
CHM
Tbio
Family: Enzyme
Novelty: 0.00226278
Score: 0.9
Data Source: STRINGDB
RAB5B
Tbio
Family: Enzyme
Novelty: 0.02653775
Score: 0.9
Data Source: STRINGDB
GDI2
Tbio
Novelty: 0.02861013
Score: 0.9
Data Source: STRINGDB
CHML
Tbio
Family: Enzyme
Novelty: 0.00509709
Score: 0.9
Data Source: STRINGDB
EEA1
Tbio
Novelty: 0.00242832
Score: 0.711
Data Source: STRINGDB
EXOC3L4
Tdark
Novelty: 0.65394237
Score: 0.711
Data Source: STRINGDB
ZMIZ2
Tbio
Family: TF
Novelty: 0.28069625
Score: 0.698
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.56

PubMed score by year
PubTator Score  2.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer