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Tdark
LCE3E
Late cornified envelope protein 3E

Protein Summary
Description
Precursors of the cornified envelope of the stratum corneum.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368789
  • ENSP00000357778
  • ENSG00000185966

Symbol
  • LEP17
  • LEP17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.47
cell line
0.46
biological term
0.33
disease
0.32
phenotype
0.3


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.09   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.09   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.3
95.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
95.9
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5T5B0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (53)
1 – 10 of 53
SPRR2B
Tdark
Novelty: 0.36342019
Score: 0.981
Data Source: STRINGDB
SPRR2G
Tdark
Novelty: 0.7198022
Score: 0.977
Data Source: STRINGDB
LCE2C
Tdark
Novelty: 4.51851552
Score: 0.975
Data Source: STRINGDB
LCE2D
Tdark
Novelty: 1.74927
Score: 0.97
Data Source: STRINGDB
SPRR2A
Tbio
Novelty: 0.07065019
Score: 0.967
Data Source: STRINGDB
LCE3D
Tdark
Novelty: 0.20614547
Score: 0.966
Data Source: STRINGDB
SPRR2E
Tdark
Novelty: 0.78347788
Score: 0.964
Data Source: STRINGDB
LCE1A
Tbio
Novelty: 0.04596696
Score: 0.957
Data Source: STRINGDB
LCE5A
Tdark
Novelty: 0.94159494
Score: 0.956
Data Source: STRINGDB
LCE2A
Tdark
Novelty: 0.42847251
Score: 0.953
Data Source: STRINGDB
Publication Statistics
PubMed Score  1.09

PubMed score by year
PubTator Score  0.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer