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Tbio
VARS2
Valine--tRNA ligase, mitochondrial

Protein Summary
Description
This gene encodes a mitochondrial aminoacyl-tRNA synthetase, which catalyzes the attachment of valine to tRNA(Val) for mitochondrial translation. Mutations in this gene cause combined oxidative phosphorylation deficiency-20, and are also associated with early-onset mitochondrial encephalopathies. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
protein domain
0.92
interacting protein
0.76
cell type or tissue
0.73
kinase perturbation
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.06   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 48   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.06   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 48   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.3
51.8
Moderate albuminuria
1
1
0
3.8
23.9
1
1
0
3.8
23.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
51.8
Moderate albuminuria
0
3.8
23.9
0
3.8
23.9
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
valyl-tRNA synthetase 2, mitochondrial
VGNC:53443
107975445
Macaque
valyl-tRNA synthetase 2, mitochondrial
106997888
Mouse
MGI:1916165
68915
Rat
RGD:1303122
309596
Dog
valyl-tRNA synthetase 2, mitochondrial
VGNC:48232
474833
Species
Name
OMA
EggNOG
Inparanoid
Chimp
valyl-tRNA synthetase 2, mitochondrial
Macaque
valyl-tRNA synthetase 2, mitochondrial
Mouse
Rat
Dog
valyl-tRNA synthetase 2, mitochondrial
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial tRNA aminoacylation
Reactome
Translation
Reactome
tRNA Aminoacylation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial tRNA aminoacylation
Translation
tRNA Aminoacylation
Gene Ontology Terms (6)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (121)
1 – 10 of 121
KISS1
Tbio
Novelty: 0.00096537
p_int: 0.999999988
p_ni: 1.1e-8
Data Source: BioPlex
UCK2
Tbio
Family: Kinase
Novelty: 0.02417595
p_int: 0.999884367
p_ni: 0.000115631
p_wrong: 1e-9
Score: 0.442
Data Source: BioPlex,STRINGDB
BPNT1
Tbio
Family: Enzyme
Novelty: 0.1114547
p_int: 0.999432726
p_ni: 0.000453519
p_wrong: 0.000113754
Score: 0.185
Data Source: BioPlex,STRINGDB
NDUFS7
Tclin
Family: Enzyme
Novelty: 0.01562198
p_int: 0.99937054
p_ni: 0.000297948
p_wrong: 0.000331513
Score: 0.245
Data Source: BioPlex,STRINGDB
LARS
Tchem
Family: Enzyme
Novelty: 0.00361711
Score: 0.965
Data Source: STRINGDB
YARS
Tchem
Family: Enzyme
Novelty: 0.00302115
Score: 0.931
Data Source: STRINGDB
MARS
Tchem
Family: Enzyme
Novelty: 0.01318702
Score: 0.929
Data Source: STRINGDB
CARS
Tbio
Family: Enzyme
Novelty: 0.02078279
Score: 0.914
Data Source: STRINGDB
EPRS
Tchem
Family: Enzyme
Novelty: 0.00084896
Score: 0.914
Data Source: STRINGDB
GARS
Tbio
Family: Enzyme
Novelty: 0.00190498
Score: 0.911
Data Source: STRINGDB
Publication Statistics
PubMed Score  101.06

PubMed score by year
PubTator Score  11.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer