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Tdark
DOP1A
Protein dopey-1

Protein Summary
Description
May be involved in protein traffic between late Golgi and early endosomes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000349129
  • ENSP00000195654
  • ENSG00000083097

Symbol
  • DOPEY1
  • KIAA1117
  • DOP1
  • DOPEY1
  • KIAA1117
  • dJ202D23.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.87
cell type or tissue
0.77
cell line
0.64
transcription factor binding site profile
0.64
virus perturbation
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.47   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 36   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.47   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 36   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
3
79.7
1
1
0
1.1
31.4
vitamin D measurement
1
1
1
26.6
platelet-derived growth factor BB measurement
1
1
1
2.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
79.7
0
1.1
31.4
vitamin D measurement
1
26.6
platelet-derived growth factor BB measurement
1
2.9
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5JWR5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (6)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
GOC
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (55)
1 – 10 of 55
VAPB
Tbio
Novelty:  0.00542377
p_int:  0.998524377
p_ni:  0.000588704
p_wrong:  0.000886919
Score:  0.188
Data Source:  BioPlex,STRINGDB
MON2
Tbio
Novelty:  0.02807677
Score:  0.923
Data Source:  STRINGDB
CFAP206
Tdark
Novelty:  1.22847252
Score:  0.774
Data Source:  STRINGDB
UBE3D
Tbio
Family:  Enzyme
Novelty:  0.44919491
Score:  0.773
Data Source:  STRINGDB
TRIP12
Tbio
Family:  Enzyme
Novelty:  0.03433452
Score:  0.769
Data Source:  STRINGDB
PUS7
Tbio
Family:  Enzyme
Novelty:  0.04867669
Score:  0.73
Data Source:  STRINGDB
CYB5R4
Tbio
Family:  Enzyme
Novelty:  0.06424571
Score:  0.726
Data Source:  STRINGDB
PUDP
Tbio
Family:  Enzyme
Novelty:  0.11180277
Score:  0.725
Data Source:  STRINGDB
PRSS35
Tbio
Family:  Enzyme
Novelty:  0.28801395
Score:  0.724
Data Source:  STRINGDB
ZKSCAN8
Tbio
Family:  TF
Novelty:  0.17881042
Score:  0.708
Data Source:  STRINGDB
Publication Statistics
PubMed Score  29.47

PubMed score by year
PubTator Score  7.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer