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Tbio
CMPK2
UMP-CMP kinase 2, mitochondrial

Protein Summary
Description
May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity. This gene encodes one of the enzymes in the nucleotide synthesis salvage pathway that may participate in terminal differentiation of monocytic cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256722
  • ENSP00000256722
  • ENSG00000134326
  • ENST00000404168
  • ENSP00000384915
  • ENST00000458098
  • ENSP00000396385

Symbol
  • NDK
  • TYKi
  • TMPK2
  • UMP-CMPK2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.99
molecular function
0.96
virus perturbation
0.95
histone modification site profile
0.85
biological process
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.4   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.4   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (128)
RSAD2
Tbio
Novelty:  0.0056473
Score:  0.967
Data Source:  STRINGDB
UMPS
Tclin
Family:  Enzyme
Novelty:  0.00848756
Score:  0.96
Data Source:  STRINGDB
NME4
Tbio
Family:  Kinase
Novelty:  0.03735196
Score:  0.96
Data Source:  STRINGDB
NME7
Tbio
Family:  Enzyme
Novelty:  0.08546782
Score:  0.955
Data Source:  STRINGDB
NT5M
Tchem
Family:  Enzyme
Novelty:  0.03299091
Score:  0.951
Data Source:  STRINGDB
NME1
Tbio
Family:  Kinase
Novelty:  0.00103216
Score:  0.95
Data Source:  STRINGDB
NME2
Tbio
Family:  Kinase
Novelty:  0.00257937
Score:  0.949
Data Source:  STRINGDB
AK9
Tbio
Family:  Kinase
Novelty:  0.06306357
Score:  0.948
Data Source:  STRINGDB
NT5C3A
Tbio
Family:  Enzyme
Novelty:  0.01939545
Score:  0.947
Data Source:  STRINGDB
NME5
Tbio
Family:  Kinase
Novelty:  0.08755237
Score:  0.941
Data Source:  STRINGDB
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
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1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytidine/uridine monophosphate kinase 2
VGNC:2928
459005
Macaque
cytidine/uridine monophosphate kinase 2
708602
Mouse
MGI:99830
22169
Rat
RGD:1305881
314004
Cow
cytidine/uridine monophosphate kinase 2
VGNC:27481
784304
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytidine/uridine monophosphate kinase 2
Macaque
cytidine/uridine monophosphate kinase 2
Mouse
Rat
Cow
cytidine/uridine monophosphate kinase 2
Publication Statistics
PubMed Score 77.40
PubMed score by year
PubTator Score 154.82
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title