You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CAVIN4
Caveolae-associated protein 4

Protein Summary
Description
Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation. Facilitates the recruitment of MAPK1/3 to caveolae within cardiomyocytes and regulates alpha-1 adrenergic receptor-induced hypertrophic responses in cardiomyocytes through MAPK1/3 activation. Contributes to proper membrane localization and stabilization of caveolin-3 (CAV3) in cardiomyocytes (By similarity). Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway (PubMed:18332105). This gene encodes a protein containing two coiled-coil regions. The encoded protein promotes Rho/ROCK (Rho-kinase) signaling in cardiac muscles cells, and may facilitate myofibrillar organization. [provided by RefSeq, Jun 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307584
  • ENSP00000418668
  • ENSG00000170681

Symbol
  • MURC
  • MURC
  • cavin-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.69   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.69   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (11)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (23)
1 – 10 of 23
TRIM54
Tbio
Novelty: 0.0198735
Score: 0.747
Data Source: STRINGDB
CAV3
Tbio
Novelty: 0.00190092
Score: 0.743
Data Source: STRINGDB
SESTD1
Tbio
Novelty: 0.2052002
Score: 0.647
Data Source: STRINGDB
DACT1
Tbio
Novelty: 0.00217915
Score: 0.643
Data Source: STRINGDB
LRRC17
Tdark
Novelty: 0.16875862
Score: 0.623
Data Source: STRINGDB
MYBPH
Tbio
Novelty: 0.00247863
Score: 0.614
Data Source: STRINGDB
CAV2
Tbio
Novelty: 0.00324146
Score: 0.612
Data Source: STRINGDB
CAV1
Tbio
Novelty: 0.00035244
Score: 0.611
Data Source: STRINGDB
TNNC2
Tbio
Novelty: 0.07759506
Score: 0.596
Data Source: STRINGDB
SIX4
Tbio
Family: TF
Novelty: 0.01783726
Score: 0.578
Data Source: STRINGDB
Publication Statistics
PubMed Score  35.69

PubMed score by year
PubTator Score  20.9

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer