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Tbio
ACTBL2
Beta-actin-like protein 2

Protein Summary
Description
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000423391
  • ENSP00000416706
  • ENSG00000169067

Symbol
  • ACT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.98
pathway
0.97
protein complex
0.84
molecular function
0.73
cell type or tissue
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.94   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 60   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.94   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
0.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
0.1
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
actin, beta like 2
VGNC:11726
471539
Mouse
MGI:2444552
238880
Rat
RGD:1309504
294732
Horse
actin, beta like 2
VGNC:15014
100051557
Opossum
actin, beta like 2
100017686
Species
Name
OMA
EggNOG
Inparanoid
Chimp
actin, beta like 2
Mouse
Rat
Horse
actin, beta like 2
Opossum
actin, beta like 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q562R1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Alzheimer disease-presenilin pathway
PathwayCommons: panther
Cadherin signaling pathway
PathwayCommons: panther
Cytoskeletal regulation by Rho GTPase
PathwayCommons: panther
Huntington disease
PathwayCommons: panther
Inflammation mediated by chemokine and cytokine signaling pathway
Name
Explore in Pharos
Explore in Source
Alzheimer disease-presenilin pathway
Cadherin signaling pathway
Cytoskeletal regulation by Rho GTPase
Huntington disease
Inflammation mediated by chemokine and cytokine signaling pathway
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (153)
1 – 10 of 153
MAP3K4
Tbio
Family:  Kinase
Novelty:  0.02186397
p_int:  0.999930518
p_ni:  0.000069482
Score:  0.179
Data Source:  BioPlex,STRINGDB
PDCL3
Tbio
Novelty:  0.05786581
p_int:  0.999869942
p_ni:  0.000130058
Score:  0.19
Data Source:  BioPlex,STRINGDB
POTEF
Tbio
Novelty:  0.00191599
p_int:  0.999758188
p_ni:  0.000241771
p_wrong:  4.2e-8
Data Source:  BioPlex
PFN3
Tdark
Novelty:  0.11291078
p_int:  0.999334591
p_ni:  0.000665409
Data Source:  BioPlex
PHACTR2
Tbio
Family:  Enzyme
Novelty:  0.25056698
p_int:  0.99921304
p_ni:  0.00078696
Score:  0.45
Data Source:  BioPlex,STRINGDB
ACTB
Tbio
Novelty:  0.00006048
p_int:  0.999201974
p_ni:  0.000798026
Score:  0.946
Data Source:  BioPlex,STRINGDB
PFN2
Tbio
Novelty:  0.00605366
p_int:  0.998884943
p_ni:  0.001115057
Score:  0.442
Data Source:  BioPlex,STRINGDB
BCL7B
Tbio
Novelty:  0.11909054
p_int:  0.998608426
p_ni:  0.00111316
p_wrong:  0.000278414
Data Source:  BioPlex
COBL
Tbio
Novelty:  0.01903038
p_int:  0.998189723
p_ni:  0.001810277
Data Source:  BioPlex
BCL7C
Tdark
Novelty:  0.31203802
p_int:  0.997957067
p_ni:  0.002042933
Data Source:  BioPlex
Publication Statistics
PubMed Score  5.94

PubMed score by year
PubTator Score  8.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer