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Tdark
VWC2
Brorin

Protein Summary
Description
BMP antagonist which may play a role in neural development. Promotes cell adhesion (By similarity). This gene encodes a secreted bone morphogenic protein antagonist. The encoded protein is possibly involved in neural function and development and may have a role in cell adhesion.[provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340652
  • ENSP00000341819
  • ENSG00000188730

Symbol
  • UNQ739
  • PSST739
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.62
cellular component
0.56
tissue
0.51
PubMedID
0.49
cell type or tissue
0.44


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.14   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.14   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
77.2
C-reactive protein measurement
1
1
1
63.1
insomnia measurement
1
1
0
1
41.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
77.2
C-reactive protein measurement
1
63.1
insomnia measurement
0
1
41.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
von Willebrand factor C domain containing 2
VGNC:50371
472363
Mouse
MGI:2442987
319922
Rat
RGD:1589624
501231
Dog
von Willebrand factor C domain containing 2
VGNC:52060
483230
Horse
von Willebrand factor C domain containing 2
VGNC:24959
100052323
Species
Name
OMA
EggNOG
Inparanoid
Chimp
von Willebrand factor C domain containing 2
Mouse
Rat
Dog
von Willebrand factor C domain containing 2
Horse
von Willebrand factor C domain containing 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q2TAL6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (9)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
HGNC
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (88)
1 – 10 of 88
TYW3
Tdark
Novelty: 0.15183348
p_int: 0.992939565
p_ni: 0.007047436
p_wrong: 0.000012999
Data Source: BioPlex
ZNF696
Tdark
Family: TF
Novelty: 3.49300122
p_int: 0.918142739
p_ni: 0.081857149
p_wrong: 1.12e-7
Data Source: BioPlex
HLA-DQA1
Tbio
Novelty: 0.00077488
p_int: 0.808796132
p_ni: 0.000024633
p_wrong: 0.191179235
Data Source: BioPlex
GRN
Tbio
Novelty: 0.00096395
p_int: 0.773105977
p_ni: 0.226889076
p_wrong: 0.000004947
Data Source: BioPlex
SHISA6
Tdark
Novelty: 0.34379596
Score: 0.775
Data Source: STRINGDB
GSG1L
Tbio
Novelty: 0.0926097
Score: 0.726
Data Source: STRINGDB
KBTBD12
Tdark
Novelty: 3.42794501
Score: 0.725
Data Source: STRINGDB
SHISA9
Tbio
Novelty: 0.10986428
Score: 0.698
Data Source: STRINGDB
KLHDC8B
Tbio
Novelty: 0.15409379
Score: 0.687
Data Source: STRINGDB
NRN1
Tbio
Novelty: 0.01198116
Score: 0.686
Data Source: STRINGDB
Publication Statistics
PubMed Score  4.14

PubMed score by year
PubTator Score  1.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer