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Tbio
UBXN2B
UBX domain-containing protein 2B

Protein Summary
Description
Adapter protein required for Golgi and endoplasmic reticulum biogenesis (PubMed:17141156). Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis (PubMed:17141156). The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L (PubMed:17141156). VCPIP1 is also required, but not its deubiquitinating activity (PubMed:17141156). Together with NSFL1C/p47, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399598
  • ENSP00000382507
  • ENSG00000215114

Symbol
  • p37
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.64
cell type or tissue
0.61
microRNA
0.61
tissue sample
0.61
histone modification site profile
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.97   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.97   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
7
6
16
96.7
sex hormone-binding globulin measurement
4
2
4
96.6
total cholesterol measurement
6
6
15
95.6
triglyceride measurement
4
3
4
83.6
testosterone measurement
2
2
2
65.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
16
96.7
sex hormone-binding globulin measurement
4
96.6
total cholesterol measurement
15
95.6
triglyceride measurement
4
83.6
testosterone measurement
2
65.7
Gene Ontology Terms (14)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (54)
1 – 10 of 54
FAM104A
Tdark
Novelty: 0.81293501
p_int: 0.999997743
p_ni: 1e-8
p_wrong: 0.000002247
Score: 0.822
Data Source: BioPlex,STRINGDB
CDC42BPB
Tbio
Family: Kinase
Novelty: 0.12012285
p_int: 0.999996665
p_ni: 0.000003335
Score: 0.6
Data Source: BioPlex,STRINGDB
ASPSCR1
Tbio
Novelty: 0.01172319
p_int: 0.999899189
p_ni: 0.000100811
Score: 0.685
Data Source: BioPlex,STRINGDB
FANK1
Tbio
Novelty: 0.12389783
p_int: 0.999894
p_ni: 0.000105999
p_wrong: 1e-9
Score: 0.226
Data Source: BioPlex,STRINGDB
VCP
Tchem
Family: Enzyme
Novelty: 0.00103317
p_int: 0.998350087
p_ni: 0.001649913
Score: 0.882
Data Source: BioPlex,STRINGDB
ACTR6
Tbio
Novelty: 0.11005766
p_int: 0.973443704
p_ni: 0.026553758
p_wrong: 0.000002537
Score: 0.161
Data Source: BioPlex,STRINGDB
PPP1R7
Tbio
Family: Enzyme
Novelty: 0.02088568
p_int: 0.939263991
p_ni: 0.060736009
Score: 0.409
Data Source: BioPlex,STRINGDB
FAM89A
Tdark
Novelty: 0.50482911
p_int: 0.937892369
p_ni: 1e-8
p_wrong: 0.06210762
Score: 0.622
Data Source: BioPlex,STRINGDB
PPP1R11
Tbio
Family: Enzyme
Novelty: 0.08166535
p_int: 0.860346607
p_ni: 0.000032023
p_wrong: 0.13962137
Score: 0.586
Data Source: BioPlex,STRINGDB
FAF1
Tbio
Novelty: 0.01526275
Score: 0.751
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.97

PubMed score by year
PubTator Score  4.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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