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Tbio
FGFBP1
Fibroblast growth factor-binding protein 1

Protein Summary
Description
Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth. This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382333
  • ENSP00000371770
  • ENSG00000137440

Symbol
  • FGFBP
  • HBP17
  • FGFBP
  • HBP17
  • FGF-BP
  • FGF-BP1
  • FGFBP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.96
gene perturbation
0.91
interacting protein
0.8
disease perturbation
0.68
transcription factor perturbation
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.7   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 201   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.7   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (7)
FGFR2 ligand binding and activation (R-HSA-190241)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
FGFR2 ligand binding and activation
Reactome
FGFR2b ligand binding and activation
Reactome
Signal Transduction
Reactome
Signaling by FGFR
Reactome
Signaling by FGFR2
Name
Explore in Pharos
Explore in Source
FGFR2 ligand binding and activation
FGFR2b ligand binding and activation
Signal Transduction
Signaling by FGFR
Signaling by FGFR2
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (43)
1 – 10 of 43
FGF7
Tbio
Novelty: 0.00066836
Score: 0.985
Data Source: Reactome,STRINGDB
FGF2
Tchem
Novelty: 0.00009754
Score: 0.98
Data Source: Reactome,STRINGDB
FGF22
Tbio
Novelty: 0.06036938
Score: 0.968
Data Source: Reactome,STRINGDB
FGF10
Tbio
Novelty: 0.00259695
Score: 0.966
Data Source: Reactome,STRINGDB
FGF1
Tchem
Novelty: 0.00060955
Score: 0.965
Data Source: STRINGDB
HSPG2
Tbio
Family: Enzyme
Novelty: 0.0008386
Score: 0.962
Data Source: STRINGDB
FGF3
Tbio
Novelty: 0.00555787
Score: 0.955
Data Source: STRINGDB
FGF13
Tbio
Novelty: 0.00105356
Score: 0.685
Data Source: STRINGDB
FOXM1
Tbio
Family: TF
Novelty: 0.00086477
Score: 0.646
Data Source: STRINGDB
FGF4
Tbio
Novelty: 0.00241958
Score: 0.6
Data Source: STRINGDB
Publication Statistics
PubMed Score  47.70

PubMed score by year
PubTator Score  31.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer