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Tbio
KLF9
Krueppel-like factor 9

Protein Summary
Description
Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box. Acts as an epidermal circadian transcription factor regulating keratinocyte proliferation (PubMed:22711835). The protein encoded by this gene is a transcription factor that binds to GC box elements located in the promoter. Binding of the encoded protein to a single GC box inhibits mRNA expression while binding to tandemly repeated GC box elements activates transcription. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377126
  • ENSP00000366330
  • ENSG00000119138

Symbol
  • BTEB
  • BTEB1
  • BTEB
  • BTEB1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.97
transcription factor perturbation
0.97
disease perturbation
0.95
transcription factor binding site profile
0.84
small molecule perturbation
0.82


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 162.65   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 218   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 162.65   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 218   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
4
4
96.8
mean platelet volume
3
3
3
88.4
heel bone mineral density
2
1
2
65.1
platelet count
2
2
2
45.3
self reported educational attainment
1
1
1
29.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
96.8
mean platelet volume
3
88.4
heel bone mineral density
2
65.1
platelet count
2
45.3
self reported educational attainment
1
29.3
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1333856
16601
Rat
RGD:70934
117560
Dog
Kruppel like factor 9
VGNC:53731
484172
Horse
Kruppel like factor 9
VGNC:19450
100050300
Cow
Kruppel like factor 9
VGNC:30632
539139
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
Kruppel like factor 9
Horse
Kruppel like factor 9
Cow
Kruppel like factor 9
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q13886-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Exercise-induced Circadian Regulation
WikiPathways
Exercise-induced Circadian Regulation
WikiPathways
Exercise-induced Circadian Regulation
WikiPathways
NRF2 pathway
WikiPathways
Arachidonate Epoxygenase / Epoxide Hydrolase
Name
Explore in Pharos
Explore in Source
Exercise-induced Circadian Regulation
Exercise-induced Circadian Regulation
Exercise-induced Circadian Regulation
NRF2 pathway
Arachidonate Epoxygenase / Epoxide Hydrolase
Protein-Protein Interactions (40)
1 – 10 of 40
PGR
Tclin
Family: NR
Novelty: 0.00008416
Score: 0.786
Data Source: STRINGDB
SIN3A
Tbio
Novelty: 0.00747207
Score: 0.656
Data Source: STRINGDB
TRPM3
Tchem
Family: IC
Novelty: 0.00647452
Score: 0.641
Data Source: STRINGDB
HOXA10
Tbio
Family: TF
Novelty: 0.00324357
Score: 0.628
Data Source: STRINGDB
ESR1
Tclin
Family: NR
Novelty: 0.00005938
Score: 0.605
Data Source: STRINGDB
NOTCH1
Tchem
Novelty: 0.00012547
Score: 0.577
Data Source: STRINGDB
THRA
Tclin
Family: NR
Novelty: 0.00171027
Score: 0.553
Data Source: STRINGDB
BMP2
Tbio
Novelty: 0.00016974
Score: 0.529
Data Source: STRINGDB
TMEM176B
Tbio
Novelty: 0.02452255
Score: 0.523
Data Source: STRINGDB
FOXN3
Tbio
Family: TF
Novelty: 0.02908033
Score: 0.522
Data Source: STRINGDB
Publication Statistics
PubMed Score  162.65

PubMed score by year
PubTator Score  59.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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