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Tbio
TBX2
T-box transcription factor TBX2

Protein Summary
Description
Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. May be required for cardiac atrioventricular canal formation. This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000240328
  • ENSP00000240328
  • ENSG00000121068

Symbol
  • VETD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.93
transcription factor perturbation
0.88
PubMedID
0.84
disease perturbation
0.79
molecular function
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.35   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 297   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.35   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 297   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (41)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
7
10
14
99.3
glomerular filtration rate
11
9
18
14.9
99.3
body height
7
4
8
96.7
BMI-adjusted waist circumference
7
12
20
95.6
hemoglobin measurement
3
2
3
92.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
14
99.3
glomerular filtration rate
18
14.9
99.3
body height
8
96.7
BMI-adjusted waist circumference
20
95.6
hemoglobin measurement
3
92.6
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
T-box 2
VGNC:9677
454800
Mouse
MGI:98494
21385
Dog
T-box 2
VGNC:47171
448779
Horse
T-box 2 [Source:HGNC Symbol;Acc:HGNC:11597]
Cow
T-box 2
VGNC:35666
535982
Species
Name
OMA
EggNOG
Inparanoid
Chimp
T-box 2
Mouse
Dog
T-box 2
Horse
T-box 2 [Source:HGNC Symbol;Acc:HGNC:11597]
Cow
T-box 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q13207-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (327)
Items per page:
1 – 5 of 327
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Kit receptor signaling pathway
WikiPathways
Kit receptor signaling pathway
WikiPathways
Kit receptor signaling pathway
WikiPathways
Kit receptor signaling pathway
WikiPathways
Kit receptor signaling pathway
Name
Explore in Pharos
Explore in Source
Kit receptor signaling pathway
Kit receptor signaling pathway
Kit receptor signaling pathway
Kit receptor signaling pathway
Kit receptor signaling pathway
Gene Ontology Terms (33)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (92)
1 – 10 of 92
CDKN2A
Tbio
Novelty:  0.00014147
Score:  0.942
Data Source:  STRINGDB
CDKN2A
Tbio
Family:  Enzyme
Novelty:  0.00014147
Score:  0.942
Data Source:  STRINGDB
NKX2-5
Tbio
Family:  TF
Novelty:  0.00125993
Score:  0.904
Data Source:  STRINGDB
BMP2
Tbio
Novelty:  0.00016974
Score:  0.814
Data Source:  STRINGDB
TFAP2A
Tbio
Family:  TF
Novelty:  0.00235655
Score:  0.719
Data Source:  STRINGDB
BMP4
Tchem
Novelty:  0.00047387
Score:  0.718
Data Source:  STRINGDB
EGR1
Tbio
Family:  TF
Novelty:  0.00039994
Score:  0.714
Data Source:  STRINGDB
GJA1
Tbio
Novelty:  0.00021332
Score:  0.68
Data Source:  STRINGDB
HEY1
Tbio
Family:  TF
Novelty:  0.0042366
Score:  0.655
Data Source:  STRINGDB
NPPA
Tchem
Novelty:  0.00046693
Score:  0.647
Data Source:  STRINGDB
Publication Statistics
PubMed Score  164.35

PubMed score by year
PubTator Score  74.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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