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Tbio
SPIB
Transcription factor Spi-B

Protein Summary
Description
Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation. The protein encoded by this gene is a transcriptional activator that binds to the PU-box (5'-GAGGAA-3') and acts as a lymphoid-specific enhancer. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270632
  • ENSP00000270632
  • ENSG00000269404
  • ENST00000439922
  • ENSP00000391877
  • ENST00000595883
  • ENSP00000471921

Symbol
  • SPI-B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.96
kinase
0.85
hub protein
0.71
transcription factor
0.69
PubMedID
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.6   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 171   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.6   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.4
79
1
1
0
1.4
77.1
systolic blood pressure
1
1
1
3.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
79
0
1.4
77.1
systolic blood pressure
1
3.8
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q01892-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (8)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
NTNU_SB
Inferred from Mutant Phenotype (IMP)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (69)
1 – 10 of 69
IRF4
Tbio
Family: TF
Novelty: 0.00192973
Score: 0.871
Data Source: STRINGDB
ID2
Tbio
Family: TF
Novelty: 0.00256364
Score: 0.74
Data Source: STRINGDB
POU2AF1
Tbio
Novelty: 0.00828018
Score: 0.717
Data Source: STRINGDB
IRF8
Tbio
Family: TF
Novelty: 0.00330143
Score: 0.692
Data Source: STRINGDB
IKZF3
Tbio
Family: TF
Novelty: 0.01038728
Score: 0.636
Data Source: STRINGDB
PAX5
Tbio
Family: TF
Novelty: 0.0012666
Score: 0.614
Data Source: STRINGDB
TNFSF11
Tclin
Novelty: 0.00018328
Score: 0.613
Data Source: STRINGDB
SATB1
Tbio
Family: TF
Novelty: 0.00434577
Score: 0.612
Data Source: STRINGDB
CSNK2A1
Tchem
Family: Kinase
Novelty: 0.00187855
Score: 0.612
Data Source: STRINGDB
NFIA
Tbio
Family: TF
Novelty: 0.00754859
Score: 0.611
Data Source: STRINGDB
Publication Statistics
PubMed Score  92.60

PubMed score by year
PubTator Score  45.11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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