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Tbio
SLC25A3
Phosphate carrier protein, mitochondrial

Protein Summary
Description
Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP). The protein encoded by this gene catalyzes the transport of phosphate into the mitochondrial matrix, either by proton cotransport or in exchange for hydroxyl ions. The protein contains three related segments arranged in tandem which are related to those found in other characterized members of the mitochondrial carrier family. Both the N-terminal and C-terminal regions of this protein protrude toward the cytosol. Multiple alternatively spliced transcript variants have been isolated. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000188376
  • ENSP00000188376
  • ENSG00000075415
  • ENST00000228318
  • ENSP00000228318
  • ENST00000401722
  • ENSP00000383898
  • ENST00000549338
  • ENSP00000447740
  • ENST00000551917
  • ENSP00000447310
  • ENST00000552981
  • ENSP00000448708

Symbol
  • PHC
  • PHC
  • PTP
  • OK/SW-cl.48
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
disease perturbation
1
kinase perturbation
1
virus perturbation
0.98
hub protein
0.88


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.37   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 47   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.37   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 47   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
1
1
1
9.4
testosterone measurement
1
1
1
6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
1
9.4
testosterone measurement
1
6
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 3
VGNC:13445
452152
Macaque
solute carrier family 25 member 3
693780
Mouse
MGI:1353498
18674
Rat
RGD:70986
245959
Dog
solute carrier family 25 member 3
475436
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 3
Macaque
solute carrier family 25 member 3
Mouse
Rat
Dog
solute carrier family 25 member 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q00325-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (170)
1 – 10 of 170
ATP5F1B
Tbio
Family:  Enzyme
Novelty:  0.01053177
Score:  0.974
Data Source:  STRINGDB
ATP5F1A
Tbio
Family:  Enzyme
Novelty:  0.01052213
Score:  0.963
Data Source:  STRINGDB
VDAC2
Tchem
Novelty:  0.00575936
Score:  0.934
Data Source:  STRINGDB
CYC1
Tchem
Novelty:  0.01369865
Score:  0.927
Data Source:  STRINGDB
ATP5PB
Tbio
Family:  Enzyme
Novelty:  0.07345384
Score:  0.916
Data Source:  STRINGDB
UQCRFS1
Tbio
Novelty:  0.00341256
Score:  0.915
Data Source:  STRINGDB
ATP5F1C
Tbio
Family:  Enzyme
Novelty:  0.07666564
Score:  0.902
Data Source:  STRINGDB
TOMM22
Tbio
Novelty:  0.01217913
Score:  0.891
Data Source:  STRINGDB
UQCRC2
Tbio
Family:  Enzyme
Novelty:  0.01584406
Score:  0.886
Data Source:  STRINGDB
TUFM
Tchem
Novelty:  0.03251632
Score:  0.883
Data Source:  STRINGDB
Publication Statistics
PubMed Score  174.37

PubMed score by year
PubTator Score  64.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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