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Tbio
PYCR2
Pyrroline-5-carboxylate reductase 2

Protein Summary
Description
Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (PubMed:2722838, PubMed:6894153). Involved in cellular response to oxidative stress (PubMed:25865492). This gene belongs to the pyrroline-5-carboxylate reductase family. The encoded mitochondrial protein catalyzes the conversion of pyrroline-5-carboxylate to proline, which is the last step in proline biosynthesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343818
  • ENSP00000342502
  • ENSG00000143811

Symbol
  • HLD10
  • P5CR2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
virus perturbation
0.85
transcription factor binding site profile
0.84
kinase perturbation
0.76
disease perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.95   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 269   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.95   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
PYCR1
Tbio
Family:  Enzyme
Novelty:  0.00220832
p_int:  0.999999898
p_ni:  1.02e-7
Score:  0.975
Data Source:  BioPlex,STRINGDB
SKA3
Tbio
Novelty:  0.05435653
p_int:  0.999999799
p_ni:  2.01e-7
Score:  0.795
Data Source:  BioPlex,STRINGDB
SKA1
Tbio
Novelty:  0.01777146
p_int:  0.999908896
p_ni:  0.000089817
p_wrong:  0.000001288
Score:  0.672
Data Source:  BioPlex,STRINGDB
NUDT5
Tbio
Family:  Enzyme
Novelty:  0.02550535
p_int:  0.999767818
p_ni:  0.000232182
Score:  0.873
Data Source:  BioPlex,STRINGDB
MYO18A
Tbio
Novelty:  0.05058328
p_int:  0.987064807
p_ni:  0.012935193
Score:  0.185
Data Source:  BioPlex,STRINGDB
MYO1F
Tbio
Novelty:  0.06367196
p_int:  0.979778766
p_ni:  0.017853942
p_wrong:  0.002367292
Score:  0.513
Data Source:  BioPlex,STRINGDB
AHNAK2
Tbio
Novelty:  0.05663435
p_int:  0.951811268
p_ni:  0.048188732
Score:  0.245
Data Source:  BioPlex,STRINGDB
PYCR3
Tbio
Family:  Enzyme
Novelty:  0.1041757
p_int:  0.891045026
p_ni:  0.108954974
Score:  0.967
Data Source:  BioPlex,STRINGDB
AHNAK
Tbio
Novelty:  0.01201996
p_int:  0.827288995
p_ni:  0.172711005
Score:  0.248
Data Source:  BioPlex,STRINGDB
ALDH4A1
Tbio
Family:  Enzyme
Novelty:  0.01316227
Score:  0.956
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (37)
Glutamate and glutamine metabolism (R-HSA-8964539)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glutamate and glutamine metabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Glutamate and glutamine metabolism
Metabolism
Metabolism of amino acids and derivatives
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
1
2
56.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
56.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
pyrroline-5-carboxylate reductase 2
699808
Mouse
MGI:1277956
69051
Rat
RGD:1310074
364064
S.cerevisiae
S000000825
856744
Species
Name
OMA
EggNOG
Inparanoid
Macaque
pyrroline-5-carboxylate reductase 2
Mouse
Rat
S.cerevisiae
Publication Statistics
PubMed Score 21.95
PubMed score by year
PubTator Score 4.61
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title