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Tdark
PTCD1
Pentatricopeptide repeat-containing protein 1, mitochondrial

Protein Summary
Description
Mitochondrial protein implicated in negative regulation of leucine tRNA levels, as well as negative regulation of mitochondria-encoded proteins and COX activity. Affects also the 3'-processing of mitochondrial tRNAs. This gene encodes a mitochondrial protein that binds leucine tRNAs and other mitochondrial RNAs and plays a role in the regulation of translation. Increased expression of this gene results in decreased mitochondrial leucine tRNA levels. Naturally occurring read-through transcription exists between upstream ATP5J2 (ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2) and this gene. [provided by RefSeq, Aug 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292478
  • ENSP00000292478
  • ENSG00000106246

Symbol
  • KIAA0632
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.85
tissue sample
0.66
interacting protein
0.65
tissue
0.62
cell type or tissue
0.6


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.46   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 31   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.46   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 31   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (98)
MRPL4
Tbio
Novelty:  0.27290276
p_int:  0.996332353
p_ni:  0.003667647
Score:  0.316
Data Source:  BioPlex,STRINGDB
RBM42
Tdark
Novelty:  0.37655036
p_int:  0.993811041
p_ni:  0.006188959
Score:  0.183
Data Source:  BioPlex,STRINGDB
ZC3H3
Tbio
Novelty:  0.26894046
p_int:  0.992041445
p_ni:  0.007958555
Data Source:  BioPlex
DDX28
Tbio
Family:  Enzyme
Novelty:  0.16760542
p_int:  0.991013588
p_ni:  0.008986412
Score:  0.789
Data Source:  BioPlex,STRINGDB
HNRNPA1
Tchem
Novelty:  0.0020871
p_int:  0.989228893
p_ni:  0.010771107
Score:  0.347
Data Source:  BioPlex,STRINGDB
MRPL30
Tdark
Novelty:  1.03623556
p_int:  0.980565664
p_ni:  0.019434248
p_wrong:  8.8e-8
Data Source:  BioPlex
MAP7
Tbio
Novelty:  0.01976296
p_int:  0.977417205
p_ni:  0.022582718
p_wrong:  7.7e-8
Data Source:  BioPlex
RBM47
Tbio
Novelty:  0.04787234
p_int:  0.951656619
p_ni:  0.048343369
p_wrong:  1.1e-8
Score:  0.167
Data Source:  BioPlex,STRINGDB
RPL6
Tbio
Novelty:  0.01742007
p_int:  0.946000252
p_ni:  0.053999748
Score:  0.246
Data Source:  BioPlex,STRINGDB
ZNF324B
Tdark
Family:  TF
Novelty:  1.89922228
p_int:  0.943927642
p_ni:  0.056072358
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (36)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hormone measurement
2
4
6
98.7
serum metabolite measurement
1
3
3
95.8
blood metabolite measurement
1
2
3
91.6
dehydroepiandrosterone sulphate measurement
1
5
10
91.5
alcohol consumption measurement
4
3
4
87.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hormone measurement
6
98.7
serum metabolite measurement
3
95.8
blood metabolite measurement
3
91.6
dehydroepiandrosterone sulphate measurement
10
91.5
alcohol consumption measurement
4
87.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 5.46
PubMed score by year
PubTator Score 2.96
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title