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Tdark
PPP1R16A
Protein phosphatase 1 regulatory subunit 16A

Protein Summary
Description
Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates. Myosin light chain kinase and phosphatase (MLCP) complexes control the phosphorylation states of regulatory myosin light chains, which is crucial for muscle and intracellular movement. MLCPs typically contain a catalytic protein phosphatase 1 (PP1c) subunit, a myosin phosphatase targeting (MYPT) subunit, and another smaller subunit. The protein encoded by this gene represents an MYPT subunit, which is responsible for directing PP1c to its intended targets. However, while other MYPTs result in PP1c activation after becoming phosphorylated, the encoded protein is phosphorylated by protein kinase A and then inhibits the catalytic activity of PP1c. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292539
  • ENSP00000292539
  • ENSG00000160972
  • ENST00000435887
  • ENSP00000391126

Symbol
  • MYPT3
  • MYPT3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.74
cell line
0.65
tissue sample
0.6
cell type or tissue
0.56
tissue
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.77   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 85   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.77   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (23)
RABGGTB
Tbio
Family:  Enzyme
Novelty:  0.06786314
p_int:  0.999992673
p_ni:  1.3e-8
p_wrong:  0.000007314
Score:  0.23
Data Source:  BioPlex,STRINGDB
CYHR1
Tdark
Novelty:  0.04771996
Score:  0.735
Data Source:  STRINGDB
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
Score:  0.735
Data Source:  STRINGDB
MROH1
Tdark
Novelty:  1.16904275
Score:  0.721
Data Source:  STRINGDB
PPP1CB
Tbio
Family:  Enzyme
Novelty:  0.0122614
Score:  0.69
Data Source:  STRINGDB
LRRC14
Tdark
Novelty:  0.67398865
Score:  0.619
Data Source:  STRINGDB
CPSF1
Tbio
Novelty:  0.04396897
Score:  0.572
Data Source:  STRINGDB
ADCK5
Tdark
Family:  Kinase
Novelty:  1.05895812
Score:  0.571
Data Source:  STRINGDB
LMNTD2
Tdark
Novelty:  4.67852257
Score:  0.568
Data Source:  STRINGDB
TRAPPC9
Tbio
Novelty:  0.02703008
Score:  0.542
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
2
1
8
94.2
mathematical ability
4
4
4
93.4
sex hormone-binding globulin measurement
6
2
6
90.7
self reported educational attainment
5
3
4
5.9
90.6
red blood cell distribution width
2
2
2
83
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
8
94.2
mathematical ability
4
93.4
sex hormone-binding globulin measurement
6
90.7
self reported educational attainment
4
5.9
90.6
red blood cell distribution width
2
83
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1920312
73062
Rat
RGD:1307962
362944
Dog
protein phosphatase 1 regulatory subunit 16A
VGNC:44884
482099
Horse
protein phosphatase 1 regulatory subunit 16A
100147459
Cow
protein phosphatase 1 regulatory subunit 16A
VGNC:33230
508701
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
protein phosphatase 1 regulatory subunit 16A
Horse
protein phosphatase 1 regulatory subunit 16A
Cow
protein phosphatase 1 regulatory subunit 16A
Publication Statistics
PubMed Score 3.77
PubMed score by year
PubTator Score 3.11
PubTator score by year
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Related Publications
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PMID
Year
Title