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Tbio
PLS1
Plastin-1

Protein Summary
Description
Actin-bundling protein in the absence of calcium. Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. The protein encoded by this gene is a third distinct plastin isoform, which is specifically expressed at high levels in the small intestine. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337777
  • ENSP00000336831
  • ENSG00000120756
  • ENST00000457734
  • ENSP00000387890
  • ENST00000497002
  • ENSP00000418700
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.93
protein domain
0.85
histone modification site profile
0.84
microRNA
0.77
transcription factor
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 191.85   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 135   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 191.85   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 135   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (132)
PLS3
Tbio
Novelty:  0.00650492
p_int:  0.99999996
p_ni:  3.5e-8
p_wrong:  5e-9
Score:  0.809
Data Source:  BioPlex,STRINGDB
LCP1
Tbio
Novelty:  0.0035357
p_int:  0.999999727
p_ni:  2.73e-7
Score:  0.555
Data Source:  BioPlex,STRINGDB
METTL6
Tdark
Family:  Enzyme
Novelty:  0.43606491
p_int:  0.999996844
p_ni:  0.000003156
Score:  0.305
Data Source:  BioPlex,STRINGDB
LIPG
Tchem
Family:  Enzyme
Novelty:  0.00412129
p_int:  0.993185195
p_ni:  0.006814805
Data Source:  BioPlex
CARTPT
Tbio
Novelty:  0.00224864
p_int:  0.988719605
p_ni:  0.011280394
p_wrong:  1e-9
Data Source:  BioPlex
FKBPL
Tbio
Novelty:  0.02054842
p_int:  0.983926715
p_ni:  0.016073279
p_wrong:  6e-9
Score:  0.168
Data Source:  BioPlex,STRINGDB
QTRT1
Tbio
Family:  Enzyme
Novelty:  0.04387363
p_int:  0.982524597
p_ni:  0.0174754
p_wrong:  4e-9
Data Source:  BioPlex
UBE2Q2
Tbio
Novelty:  0.12491522
p_int:  0.981238606
p_ni:  0.018429051
p_wrong:  0.000332343
Data Source:  BioPlex
OTUD3
Tbio
Novelty:  0.11839931
p_int:  0.978356393
p_ni:  0.021585421
p_wrong:  0.000058186
Data Source:  BioPlex
GSTM3
Tbio
Family:  Enzyme
Novelty:  0.0078192
p_int:  0.973184091
p_ni:  0.026815885
p_wrong:  2.3e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
3
3
3
96.7
red blood cell density measurement
2
2
2
94.5
mean corpuscular hemoglobin concentration
2
2
2
90.5
mean reticulocyte volume
1
1
1
88.2
reticulocyte count
4
2
4
85.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
3
96.7
red blood cell density measurement
2
94.5
mean corpuscular hemoglobin concentration
2
90.5
mean reticulocyte volume
1
88.2
reticulocyte count
4
85.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
plastin 1
VGNC:2513
460746
Mouse
MGI:104809
102502
Dog
plastin 1
VGNC:44711
485697
Horse
plastin 1
VGNC:21594
100051261
Cow
plastin 1
VGNC:33051
616560
Species
Name
OMA
EggNOG
Inparanoid
Chimp
plastin 1
Mouse
Dog
plastin 1
Horse
plastin 1
Cow
plastin 1
Publication Statistics
PubMed Score 191.85
PubMed score by year
PubTator Score 217.33
PubTator score by year
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Related Publications
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PMID
Year
Title