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Tbio
PIP4P2
Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

Protein Summary
Description
Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate. TMEM55A catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000285419
  • ENSP00000285419
  • ENSG00000155099

Symbol
  • TMEM55A
  • TMEM55A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.36   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 34   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.36   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 34   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
ARC
Tbio
Novelty:  0.00378953
p_int:  0.99989438
p_ni:  0.000105618
p_wrong:  3e-9
Score:  0.345
Data Source:  BioPlex,STRINGDB
F10
Tclin
Family:  Enzyme
Novelty:  0.00063008
p_int:  0.99985562
p_ni:  0.000041382
p_wrong:  0.000102999
Data Source:  BioPlex
EIF2B5
Tbio
Novelty:  0.0102209
p_int:  0.999847149
p_ni:  0.000067763
p_wrong:  0.000085087
Data Source:  BioPlex
SLC39A5
Tbio
Family:  Transporter
Novelty:  0.05205571
p_int:  0.999837498
p_ni:  0.000053049
p_wrong:  0.000109453
Data Source:  BioPlex
TBC1D9
Tbio
Novelty:  0.20059899
p_int:  0.999705407
p_ni:  0.000055304
p_wrong:  0.000239289
Score:  0.228
Data Source:  BioPlex,STRINGDB
GDPD5
Tbio
Family:  Enzyme
Novelty:  0.05871733
p_int:  0.999591301
p_ni:  0.000058735
p_wrong:  0.000349964
Data Source:  BioPlex
SGSM1
Tbio
Novelty:  0.27948733
p_int:  0.999203077
p_ni:  0.000044647
p_wrong:  0.000752276
Data Source:  BioPlex
F9
Tchem
Family:  Enzyme
Novelty:  0.00032127
p_int:  0.92530182
p_ni:  0.00031428
p_wrong:  0.0743839
Score:  0.183
Data Source:  BioPlex,STRINGDB
CDK5RAP3
Tbio
Novelty:  0.03628071
p_int:  0.834514428
p_ni:  0.00040085
p_wrong:  0.165084722
Score:  0.347
Data Source:  BioPlex,STRINGDB
PIP4K2A
Tbio
Family:  Kinase
Novelty:  0.01130885
Score:  0.93
Data Source:  STRINGDB
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
1
1
74.4
self reported educational attainment
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
74.4
self reported educational attainment
1
24.5
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2
VGNC:782
464281
Mouse
MGI:1919769
72519
Rat
RGD:1306225
362490
Dog
phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2
VGNC:44574
477939
Horse
phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2
VGNC:21466
100050790
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2
Mouse
Rat
Dog
phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2
Horse
phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2
Publication Statistics
PubMed Score 1.36
PubMed score by year
PubTator Score 0.33
PubTator score by year
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Related Publications
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PMID
Year
Title