You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PIFO
Protein pitchfork

Protein Summary
Description
During primary cilia disassembly, involved in cilia disassembly. Required specifically to control cilia retraction as well as the liberation and duplication of the basal body/centrosome. May act by stimulating AURKA activity at the basal body in a cell cycle-dependent manner.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369737
  • ENSP00000358752
  • ENSG00000173947
  • ENST00000369738
  • ENSP00000358753

Symbol
  • C1orf88
  • C1orf88
  • pitchfork
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.73
cellular component
0.69
cell line
0.57
molecular function
0.53
PubMedID
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.75   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 4   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.75   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 4   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (83)
ANAPC1
Tbio
Family:  Enzyme
Novelty:  0.0521845
p_int:  0.98571859
p_ni:  0.01428141
Score:  0.193
Data Source:  BioPlex,STRINGDB
PSMG3
Tchem
Novelty:  0.01730294
p_int:  0.984913174
p_ni:  0.015086781
p_wrong:  4.5e-8
Score:  0.177
Data Source:  BioPlex,STRINGDB
DUSP28
Tbio
Family:  Enzyme
Novelty:  0.0339081
p_int:  0.918887674
p_ni:  0.000340658
p_wrong:  0.080771668
Score:  0.403
Data Source:  BioPlex,STRINGDB
CSNK1G1
Tchem
Family:  Kinase
Novelty:  0.10919141
p_int:  0.89091428
p_ni:  0.005859326
p_wrong:  0.103226394
Score:  0.332
Data Source:  BioPlex,STRINGDB
GNAQ
Tbio
Novelty:  0.0008997
p_int:  0.848705382
p_ni:  0.151289361
p_wrong:  0.000005257
Data Source:  BioPlex
DAAM1
Tbio
Novelty:  0.02143008
p_int:  0.76095575
p_ni:  0.239044245
p_wrong:  5e-9
Score:  0.205
Data Source:  BioPlex,STRINGDB
EPHA2
Tclin
Family:  Kinase
Novelty:  0.00191002
p_int:  0.757249181
p_ni:  0.242748034
p_wrong:  0.000002785
Score:  0.177
Data Source:  BioPlex,STRINGDB
LAMA5
Tbio
Novelty:  0.02247145
Score:  0.742
Data Source:  STRINGDB
IFT88
Tbio
Novelty:  0.00727114
Score:  0.739
Data Source:  STRINGDB
CCP110
Tbio
Novelty:  0.02399511
Score:  0.714
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
1
1
71.8
neutrophil count
1
1
1
18.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
71.8
neutrophil count
1
18.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
primary cilia formation
VGNC:1455
457113
Macaque
primary cilia formation
703515
Mouse
MGI:1923670
100503311
Rat
RGD:1586282
691223
Dog
protein pitchfork-like
611691
Species
Name
OMA
EggNOG
Inparanoid
Chimp
primary cilia formation
Macaque
primary cilia formation
Mouse
Rat
Dog
protein pitchfork-like
Publication Statistics
PubMed Score 16.75
PubMed score by year
PubTator Score 91.67
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title