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Tdark
PCDHGB1
Protocadherin gamma-B1

Protein Summary
Description
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000523390
  • ENSP00000429273
  • ENSG00000254221
  • ENST00000611598
  • ENSP00000478900

Symbol
  • PCDH-GAMMA-B1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.7
protein domain
0.58
microRNA
0.5
tissue
0.49
cell line
0.47


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.41   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.41   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (74)
PCDHGB2
Tdark
Novelty:  1.16587709
p_int:  1
Score:  0.436
Data Source:  BioPlex,STRINGDB
PCDHGB4
Tdark
Novelty:  0.25018904
p_int:  0.999999998
p_wrong:  2e-9
Score:  0.266
Data Source:  BioPlex,STRINGDB
PCDHGB3
Tdark
Novelty:  1.9379995
p_int:  0.999999989
p_ni:  1.1e-8
Score:  0.639
Data Source:  BioPlex,STRINGDB
PCDHGC3
Tbio
Novelty:  0.07203024
p_int:  0.999999902
p_ni:  9.8e-8
Score:  0.201
Data Source:  BioPlex,STRINGDB
PCDHGA11
Tdark
Novelty:  0.44130091
p_int:  0.999999901
p_ni:  9.9e-8
Score:  0.202
Data Source:  BioPlex,STRINGDB
PCDHB2
Tdark
Novelty:  1.09706645
p_int:  0.999999899
p_wrong:  1.01e-7
Score:  0.284
Data Source:  BioPlex,STRINGDB
PCDHGC4
Tdark
Novelty:  0.79832188
p_int:  0.999999899
p_ni:  1.01e-7
Score:  0.253
Data Source:  BioPlex,STRINGDB
PCDH18
Tbio
Novelty:  0.1358594
p_int:  0.999999899
p_ni:  9.4e-8
p_wrong:  7e-9
Score:  0.228
Data Source:  BioPlex,STRINGDB
CDH3
Tbio
Novelty:  0.00295114
p_int:  0.999999733
p_ni:  2e-9
p_wrong:  2.65e-7
Score:  0.178
Data Source:  BioPlex,STRINGDB
PCDHGB5
Tdark
Novelty:  4.39427151
p_int:  0.999999675
p_ni:  2.27e-7
p_wrong:  9.8e-8
Score:  0.713
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Cadherin signaling pathway
PathwayCommons: panther
Wnt signaling pathway
Name
Explore in Pharos
Explore in Source
Cadherin signaling pathway
Wnt signaling pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
4
6
93.5
self reported educational attainment
2
2
2
57.1
triglyceride measurement
1
1
1
47.7
1
1
0
1
46.5
age at first birth measurement
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
6
93.5
self reported educational attainment
2
57.1
triglyceride measurement
1
47.7
0
1
46.5
age at first birth measurement
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 1.41
PubMed score by year
PubTator Score 0.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title