Protein Summary
Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions (By similarity). Acts as a regulator of cell migration, probably via increasing cell-cell adhesion (PubMed:21402705). Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions (By similarity). Unable to bind to catenins, weakly associates with the cytoskeleton (By similarity). This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 6 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene localizes to the region on chromosome 5 where the protocadherin gene clusters reside. The exon organization of this transcript is similar to that of the gene cluster transcripts, notably the first large exon, but no significant sequence homology exists. The function of this c ...more
- ENST00000231484
- ENSP00000231484
- ENSG00000113555
- VECAD2
- VE-cadherin-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
cell line | 0.66 | ||
tissue sample | 0.64 | ||
protein domain | 0.58 | ||
small molecule perturbation | 0.54 | ||
tissue | 0.51 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19.39 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 86 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19.39 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 86 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (36)
PCDH10
Novelty: 0.01058382
p_int: 0.999998707
p_ni: 0.000001293
Score: 0.297
Data Source: BioPlex,STRINGDB
PCDH17
Novelty: 0.03341603
p_int: 0.999997475
p_ni: 0.000002313
p_wrong: 2.12e-7
Score: 0.812
Data Source: BioPlex,STRINGDB
CLIC3
Family: IC
Novelty: 0.07268934
p_int: 0.999994826
p_ni: 0.000005057
p_wrong: 1.17e-7
Score: 0.26
Data Source: BioPlex,STRINGDB
PCDHGA11
Novelty: 0.44130091
p_int: 0.999991974
p_ni: 0.000008025
p_wrong: 1e-9
Score: 0.185
Data Source: BioPlex,STRINGDB
DCBLD1
Novelty: 0.21754882
p_int: 0.999988052
p_ni: 0.000011932
p_wrong: 1.6e-8
Score: 0.235
Data Source: BioPlex,STRINGDB
CDON
Novelty: 0.00447262
p_int: 0.999942382
p_ni: 0.00005754
p_wrong: 7.8e-8
Score: 0.175
Data Source: BioPlex,STRINGDB
PTPRS
Family: Enzyme
Novelty: 0.00587115
p_int: 0.999941342
p_ni: 0.000058657
Score: 0.22
Data Source: BioPlex,STRINGDB
PCDHGC3
Novelty: 0.07203024
p_int: 0.999938912
p_ni: 0.000061088
Score: 0.171
Data Source: BioPlex,STRINGDB
TMTC4
Novelty: 0.53734704
p_int: 0.999399341
p_ni: 0.000600657
p_wrong: 2e-9
Score: 0.193
Data Source: BioPlex,STRINGDB
LTBP1
Novelty: 0.00958396
p_int: 0.99925543
p_ni: 0.000744565
p_wrong: 6e-9
Score: 0.155
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (2)
PathwayCommons (2)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
PathwayCommons: panther | Cadherin signaling pathway | ||||
PathwayCommons: panther | Wnt signaling pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cadherin signaling pathway | ||||
Wnt signaling pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (1)
Components (4)
Processes (6)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
neutrophil percentage of leukocytes | 1 | 1 | 1 | 73.9 | |||||
lymphocyte percentage of leukocytes | 1 | 1 | 1 | 67.9 | |||||
mean platelet volume | 1 | 1 | 1 | 54.4 | |||||
insomnia measurement | 1 | 1 | 0 | 1 | 44.2 | ||||
eosinophil count | 1 | 1 | 1 | 8.1 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
neutrophil percentage of leukocytes | 1 | 73.9 | |||||
lymphocyte percentage of leukocytes | 1 | 67.9 | |||||
mean platelet volume | 1 | 54.4 | |||||
insomnia measurement | 0 | 1 | 44.2 | ||||
eosinophil count | 1 | 8.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | protocadherin 12 | VGNC:4120 | 471677 | |||||
Macaque | protocadherin 12 | 705232 | ||||||
Mouse | MGI:1855700 | 53601 | ||||||
Rat | RGD:619917 | 116808 | ||||||
Dog | protocadherin 12 | VGNC:44295 | 487191 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | protocadherin 12 | |||||
Macaque | protocadherin 12 | |||||
Mouse | ||||||
Rat | ||||||
Dog | protocadherin 12 | |||||
Publication Statistics
PubMed Score 19.39
PubMed score by year
PubTator Score 8.86
PubTator score by year
Related Publications
Text Mined References (16)
GeneRif Annotations (5)
Items per page:
0 of 0
PMID | Year | Title |
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