You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PCDH12
Protocadherin-12

Protein Summary
Description
Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions (By similarity). Acts as a regulator of cell migration, probably via increasing cell-cell adhesion (PubMed:21402705). Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions (By similarity). Unable to bind to catenins, weakly associates with the cytoskeleton (By similarity). This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 6 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene localizes to the region on chromosome 5 where the protocadherin gene clusters reside. The exon organization of this transcript is similar to that of the gene cluster transcripts, notably the first large exon, but no significant sequence homology exists. The function of this c ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000231484
  • ENSP00000231484
  • ENSG00000113555

Symbol
  • VECAD2
  • VE-cadherin-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.66
tissue sample
0.64
protein domain
0.58
small molecule perturbation
0.54
tissue
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.39   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 86   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.39   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
PCDH10
Tbio
Novelty:  0.01058382
p_int:  0.999998707
p_ni:  0.000001293
Score:  0.297
Data Source:  BioPlex,STRINGDB
PCDH17
Tbio
Novelty:  0.03341603
p_int:  0.999997475
p_ni:  0.000002313
p_wrong:  2.12e-7
Score:  0.812
Data Source:  BioPlex,STRINGDB
CLIC3
Tbio
Family:  IC
Novelty:  0.07268934
p_int:  0.999994826
p_ni:  0.000005057
p_wrong:  1.17e-7
Score:  0.26
Data Source:  BioPlex,STRINGDB
PCDHGA11
Tdark
Novelty:  0.44130091
p_int:  0.999991974
p_ni:  0.000008025
p_wrong:  1e-9
Score:  0.185
Data Source:  BioPlex,STRINGDB
DCBLD1
Tbio
Novelty:  0.21754882
p_int:  0.999988052
p_ni:  0.000011932
p_wrong:  1.6e-8
Score:  0.235
Data Source:  BioPlex,STRINGDB
CDON
Tbio
Novelty:  0.00447262
p_int:  0.999942382
p_ni:  0.00005754
p_wrong:  7.8e-8
Score:  0.175
Data Source:  BioPlex,STRINGDB
PTPRS
Tchem
Family:  Enzyme
Novelty:  0.00587115
p_int:  0.999941342
p_ni:  0.000058657
Score:  0.22
Data Source:  BioPlex,STRINGDB
PCDHGC3
Tbio
Novelty:  0.07203024
p_int:  0.999938912
p_ni:  0.000061088
Score:  0.171
Data Source:  BioPlex,STRINGDB
TMTC4
Tdark
Novelty:  0.53734704
p_int:  0.999399341
p_ni:  0.000600657
p_wrong:  2e-9
Score:  0.193
Data Source:  BioPlex,STRINGDB
LTBP1
Tbio
Novelty:  0.00958396
p_int:  0.99925543
p_ni:  0.000744565
p_wrong:  6e-9
Score:  0.155
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Cadherin signaling pathway
PathwayCommons: panther
Wnt signaling pathway
Name
Explore in Pharos
Explore in Source
Cadherin signaling pathway
Wnt signaling pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
1
1
1
73.9
lymphocyte percentage of leukocytes
1
1
1
67.9
mean platelet volume
1
1
1
54.4
insomnia measurement
1
1
0
1
44.2
eosinophil count
1
1
1
8.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
1
73.9
lymphocyte percentage of leukocytes
1
67.9
mean platelet volume
1
54.4
insomnia measurement
0
1
44.2
eosinophil count
1
8.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protocadherin 12
VGNC:4120
471677
Macaque
protocadherin 12
705232
Mouse
MGI:1855700
53601
Rat
RGD:619917
116808
Dog
protocadherin 12
VGNC:44295
487191
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protocadherin 12
Macaque
protocadherin 12
Mouse
Rat
Dog
protocadherin 12
Publication Statistics
PubMed Score 19.39
PubMed score by year
PubTator Score 8.86
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title