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Tbio
GNG3
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3

Protein Summary
Description
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The gamma subunit determines the specificity of which signaling pathways will be affected by this particular complex. The protein encoded by this gene represents the gamma subunit of both inhibitory and stimulatory complexes. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294117
  • ENSP00000294117
  • ENSG00000162188

Symbol
  • GNGT3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.8
biological process
0.79
pathway
0.76
small molecule perturbation
0.7
disease perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.65   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.65   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (574)
GNAT2
Tbio
Novelty:  0.01683655
p_int:  0.99999761
p_ni:  0.000002387
p_wrong:  3e-9
Score:  0.96
Data Source:  BioPlex,STRINGDB
GNAQ
Tbio
Novelty:  0.0008997
p_int:  0.999981091
p_ni:  0.000018909
Score:  0.964
Data Source:  BioPlex,STRINGDB
GNAO1
Tbio
Novelty:  0.00315097
p_int:  0.999979135
p_ni:  0.000020865
Score:  0.993
Data Source:  BioPlex,STRINGDB
GNA13
Tbio
Novelty:  0.04149138
p_int:  0.999962055
p_ni:  0.000037945
Score:  0.957
Data Source:  BioPlex,STRINGDB
GNB4
Tbio
Novelty:  0.08250797
p_int:  0.999960626
p_ni:  0.000039372
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
GNAZ
Tbio
Novelty:  0.02008523
p_int:  0.9998674
p_ni:  0.000132352
p_wrong:  2.48e-7
Score:  0.969
Data Source:  BioPlex,STRINGDB
GNA11
Tchem
Novelty:  0.00128664
p_int:  0.999800076
p_ni:  0.000199924
Score:  0.958
Data Source:  BioPlex,STRINGDB
FLNC
Tbio
Novelty:  0.00463205
p_int:  0.99486241
p_ni:  0.00513759
Data Source:  BioPlex
GNB1
Tbio
Novelty:  0.02477955
p_int:  0.979394296
p_ni:  0.020605704
Score:  0.999
Data Source:  BioPlex,STRINGDB
GNAI2
Tchem
Novelty:  0.03014729
p_int:  0.951374465
p_ni:  0.048625535
Score:  0.982
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (26)
Explore Nearest Tclin Targets
1 – 5 of 16
CHRM2
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
CHRM1
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
F2R
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
CNR1
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  1
GABBR1
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
Pathways (112)
ADP signalling through P2Y purinoceptor 1 (R-HSA-418592)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 59
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ADP signalling through P2Y purinoceptor 1
Reactome
ADP signalling through P2Y purinoceptor 12
Reactome
Activation of G protein gated Potassium channels
Reactome
Activation of GABAB receptors
Reactome
Activation of kainate receptors upon glutamate binding
Name
Explore in Pharos
Explore in Source
ADP signalling through P2Y purinoceptor 1
ADP signalling through P2Y purinoceptor 12
Activation of G protein gated Potassium channels
Activation of GABAB receptors
Activation of kainate receptors upon glutamate binding
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
5
9
80.9
blood protein measurement
2
2
2
80.7
triglyceride measurement
2
2
2
79.6
educational attainment
1
3
3
71.8
BMI-adjusted waist circumference
2
2
4
62.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
9
80.9
blood protein measurement
2
80.7
triglyceride measurement
2
79.6
educational attainment
3
71.8
BMI-adjusted waist circumference
4
62.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein subunit gamma 3
VGNC:10183
740869
Mouse
MGI:102704
14704
Rat
RGD:620805
114117
Dog
G protein subunit gamma 3
VGNC:41320
483783
Horse
G protein subunit gamma 3
VGNC:18432
100063795
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein subunit gamma 3
Mouse
Rat
Dog
G protein subunit gamma 3
Horse
G protein subunit gamma 3
Publication Statistics
PubMed Score 12.65
PubMed score by year
PubTator Score 1.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title