You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
GNG3
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3

Protein Summary
Description
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The gamma subunit determines the specificity of which signaling pathways will be affected by this particular complex. The protein encoded by this gene represents the gamma subunit of both inhibitory and stimulatory complexes. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294117
  • ENSP00000294117
  • ENSG00000162188

Symbol
  • GNGT3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.8
biological process
0.79
pathway
0.76
small molecule perturbation
0.7
disease perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.79   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.79   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (112)
ADP signalling through P2Y purinoceptor 1 (R-HSA-418592)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 59
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ADP signalling through P2Y purinoceptor 1
Reactome
ADP signalling through P2Y purinoceptor 12
Reactome
Activation of G protein gated Potassium channels
Reactome
Activation of GABAB receptors
Reactome
Activation of kainate receptors upon glutamate binding
Name
Explore in Pharos
Explore in Source
ADP signalling through P2Y purinoceptor 1
ADP signalling through P2Y purinoceptor 12
Activation of G protein gated Potassium channels
Activation of GABAB receptors
Activation of kainate receptors upon glutamate binding
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (574)
1 – 10 of 574
GNAT2
Tbio
Novelty: 0.02455598
p_int: 0.99999761
p_ni: 0.000002387
p_wrong: 3e-9
Score: 0.96
Data Source: BioPlex,STRINGDB
GNAQ
Tbio
Novelty: 0.00176666
p_int: 0.999981091
p_ni: 0.000018909
Score: 0.964
Data Source: BioPlex,STRINGDB
GNAO1
Tbio
Novelty: 0.0056926
p_int: 0.999979135
p_ni: 0.000020865
Score: 0.993
Data Source: BioPlex,STRINGDB
GNA13
Tbio
Novelty: 0.05970556
p_int: 0.999962055
p_ni: 0.000037945
Score: 0.957
Data Source: BioPlex,STRINGDB
GNB4
Tbio
Novelty: 0.1530232
p_int: 0.999960626
p_ni: 0.000039372
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
GNAZ
Tbio
Novelty: 0.02343957
p_int: 0.9998674
p_ni: 0.000132352
p_wrong: 2.48e-7
Score: 0.969
Data Source: BioPlex,STRINGDB
GNA11
Tbio
Novelty: 0.00156526
p_int: 0.999800076
p_ni: 0.000199924
Score: 0.958
Data Source: BioPlex,STRINGDB
FLNC
Tbio
Novelty: 0.00112022
p_int: 0.99486241
p_ni: 0.00513759
Data Source: BioPlex
GNB1
Tbio
Novelty: 0.04716243
p_int: 0.979394296
p_ni: 0.020605704
Score: 0.999
Data Source: BioPlex,STRINGDB
GNAI2
Tbio
Novelty: 0.04542644
p_int: 0.951374465
p_ni: 0.048625535
Score: 0.982
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  5.79

PubMed score by year
PubTator Score  1.89

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer