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Tbio
TMEM33
Transmembrane protein 33

Protein Summary
Description
Acts as a regulator of the tubular endoplasmic reticulum (ER) network. Suppresses the RTN3/4-induced formation of the ER tubules (PubMed:25612671). Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling (PubMed:26268696).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325094
  • ENSP00000441455
  • ENSG00000109133
  • ENST00000504986
  • ENSP00000422473
  • ENST00000513702
  • ENSP00000427006

Symbol
  • DB83
  • Pom33
  • SHINC3
  • SHINC-3
  • 1600019D15Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
interacting protein
0.92
microRNA
0.92
virus perturbation
0.88
transcription factor binding site profile
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.04   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.04   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (52)
1 – 10 of 52
ANKRD50
Tdark
Novelty:  0.7929169
Score:  0.739
Data Source:  STRINGDB
DCAF4L1
Tdark
Novelty:  4.17944542
Score:  0.729
Data Source:  STRINGDB
ARL9
Tdark
Family:  Enzyme
Novelty:  0.87210932
Score:  0.728
Data Source:  STRINGDB
ADAD1
Tbio
Family:  Enzyme
Novelty:  0.05906067
Score:  0.66
Data Source:  STRINGDB
BEND4
Tdark
Novelty:  0.54833345
Score:  0.659
Data Source:  STRINGDB
TAPT1
Tbio
Novelty:  0.12057711
Score:  0.656
Data Source:  STRINGDB
RTN4
Tbio
Novelty:  0.00080371
Score:  0.652
Data Source:  STRINGDB
RTN1
Tbio
Novelty:  0.01828064
Score:  0.632
Data Source:  STRINGDB
SRP72
Tbio
Novelty:  0.03264445
Score:  0.628
Data Source:  STRINGDB
TMEM208
Tdark
Novelty:  0.63059333
Score:  0.626
Data Source:  STRINGDB
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1
42.3
1
1
0
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1
42.3
0
1
42.3
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 33
VGNC:720
461187
Macaque
transmembrane protein 33
702063
Mouse
MGI:1915128
67878
Rat
RGD:708371
59303
Dog
transmembrane protein 33
VGNC:47571
612937
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 33
Macaque
transmembrane protein 33
Mouse
Rat
Dog
transmembrane protein 33
Publication Statistics
PubMed Score 8.04
PubMed score by year
PubTator Score 1.18
PubTator score by year